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  • 1985-1989  (5)
  • 1975-1979  (6)
  • Organic Chemistry  (9)
  • Gastroduodenal ulcer  (2)
  • 1
    Electronic Resource
    Electronic Resource
    182. Verfahrenswahl beim perforierten Gastroduodenalulcus: Definitive Operation oder einfache übernähung? (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 741-741 
    Details
    ISSN: 1435-2451
    Keywords: Gastroduodenal ulcer ; Perforation ; Prognostic criteria ; Indication ; Gastroduodenalulcus ; Perforation ; Prognostische Kriterien ; Verfahrenswahl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die hohe Morbidität (20–65% Ulcussymptome, 5–20% Ulcuskomplikationen, 20–39% Reoperationen) nach Excision und übernähung bei Patienten mit Ulcusperforation auchohne Ulcusanamnese spricht für die primäre, definitive Operation. Um das erhöhte Operationsrisiko auszuschalten, faßten wir 4 Risikofaktoren (Alter 〉 70, Intervall Perf./Op. 〉 24 h, schwere Begleitkrankheiten, diffuse Peritonitis) und die Ulcusanamnese 〈 3 Monate zu einem 5-Punktesystem zusammen. Patienten mit ≤ 3 Pt. wurden definitiv operiert (Excision/übernähung/PSV oder Resektion), Patienten mit ≥ 4 Pt. nur excidiert und übernäht. Die Gesamtletalität in dieser Serie von 51 Patienten (79–83) war dabei signifikant geringer (2 Patienten verstorben von 51; 4%) als in einer Serie mit grundsätzlicher definitiver Operation (5 verstorben von 64, 8%) (p 〈 0,025).
    Notes: Summary The high morbidity (20%–65% ulcer symptoms, 5%–20% ulcer complications, 20%–39% reoperations) after excision and simple closure of perforated ulcers that also occurs among patientswithout an ulcer history indicates that definitive operation is the treatment of choice. To identify patients with a high risk of mortality, a critical scoring system was devised according to whether the duration of the ulcer history exceeded 3 months and according to four risk factors: (1) age 〉 70 years, (2) time between perforation and operation 〉 24 h, (3) severe concomitant disease, and (4) diffuse peritonitis. Patients who scored ≤ 3 points underwent definitive surgery (excision, closure, proximal gastric vagotomy or partial gastrectomy), and patients who scored ≥ 4 points underwent only excision and simple closure. The overall mortality (2 of 51 patients died) of 4% was significantly lower than that of a previous group (8%) treated with definitive surgery, in which 5 of 64 patients died (p 〈 0.025).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274500
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  • 2
    Electronic Resource
    Electronic Resource
    319. Die proximal selektive Vagotomie beim gastroduodenalen Ulcus -10-Jahres-Ergebnisse der europäischen multizentrischen Studie (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 935-935 
    Details
    ISSN: 1435-2451
    Keywords: Proximal gastric vagotomy ; Gastroduodenal ulcer ; Ten-year results ; Proximal selektive Vagotomie ; Gastroduodenales Ulcus ; 10-Jahres-Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über die 10-Jahres-Ergebnisse einer prospektiven multizentrischen Studie an 8 europäischen Kliniken (Basel, Bern, Düsseldorf, Erlangen, Freiburg, Krefeld, München Klinikum Grosshadern, Strassburg) zur Bewertung der proximal selektiven Vagotomie beim gastroduodenalen Ulcus. Die Nachuntersuchungsrate war 81%. Ergebnis:n symptomatisch total Visick Ulcustyp % Rezidivrate % 1 + II Ulcus duodeni524 13,6 20,4 88% Ulcus ventriculi 71 13,5 19,8 73% Ulcus pyloricum/praepyloricum 94 18,7 31,684% Kombinierte Ulcera 28 27,9 31,7 82%
    Notes: Summary We report the 10-year results of a prospective multicenter trial in eight European centers (Basel, Bern, Düsseldorf, Erlangen, Freiburg, Krefeld, München Klinikum Grosshadern, Strassburg) evaluating proximal gastric vagotomy for gastroduodenal ulcers. The follow-up rate was 81%. Results:n Symptomatic Total Visick Ulcer type recurrencerecurrence I + II (%) (%) Duodenal ulcer 524 13.6 20.488% Gastric ulcer 71 13.5 19.8 73% Pyloric/prepyloric ulcer 94 18.7 31.6 84% Combined ulcer 28 27.9 31.782%
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298104
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  • 3
    Electronic Resource
    Electronic Resource
    Condensed Heterotricycles. Synthesis and Reactions of b-Fused 1(2H)-Isoquinolinones with unusual enaminic propertiesContribution No. 822 from Hindustan Ciba-Geigy Ltd., Research Centre. (1988)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 71 (1988), S. 77-92 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Homophthalic acid (1) undergoes reaction with 1,2-, 1,3-, and 1,4-diamines to give condensed 1(2H)-isoquinolinones like 2, 4, 13, and 25, which exhibit marked enamine character. These are attacked by electrophiles at the N or C terminus. Some notable reactions of imidazoisoquinolone 2 are those with maleic and acrylic acids to form the tetracycles 48 and 51, respectively. With propiolic acid, 5 underwent an interesting reaction to form the benzimidazonaphthyridine 53. An equally interesting behaviour was elicited from 2 in its reaction with formaldehyde, when in addition to the expected methylene-bridged molecule 59, the novel spiro derivative 60 was formed by the dimerisation of a presumed azadiene intermediate 63.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19880710110
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  • 4
    Electronic Resource
    Electronic Resource
    Photooxygenation of 3,3-dialkylsubstituted allyl alcohols. Occurrence of syn preference in the ene addition of 1O2 at E/Z-isomeric allyl alcohols (1979)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 62 (1979), S. 816-829 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dye-sensitized photooxygenation (1O2-reaction) of the symmetrically 3,3-dialkyl-substituted allyl alcohols 1-6 (A, Table 1) and the E- and Z-isomers of the 3-methyl-3-alkylsubstituted allyl alcohols 7-11 (A1, Table 2) has been studied. The α, β-epoxyaldehydes B and B1 and the β-hydroperoxy-homoallyl alcohols C, C1 and D1 were practically the sole oxygenation products formed. The rate and selectivity of the 1O2 additions were found to be markedly dependent on the degree of substitution (i.e. H-availability) at the allyl position which is Z-orientated to the carbinol group. The allyl alcohols with a Z-3-methyl group, 1 and the E-isomers of 7 to 10, showed practically the same reactivity towards 1O2 and formed only the two oxygenation products of type B1 and C1 (ratio close to 60:40). In contrast, the allyl alcohols with a Z-3-methylene group, 2 and the Z-isomers of 7 to 9, reacted more slowly with 1O2 and yielded all the three possible products B1, C1 and D1 in a very different ratio of ∼ 80:10:10. However, from both the E- and Z-isomers of the alcohols 7 to 10 the formations of the two oxygenation products were always strongly favoured (85-100%) which result from 1O2 additions at the disubstituted side of the double bond. This behaviour is thus completely analogous to that of the corresponding trisubstituted olefins previously studied [1]The same side-specific selectivity in 1O2 ene additions to several E/Z-isomeric and deuterium-labelled olefins has also been described recently by C.M. Stephenson et al. [2] (we thank Dr. V. Rautenstrauch and Prof. C.W. Jefford for informing us about this work). The similar behaviour of enol ethers, which react with 1O2 preferentially at the RO-substituted side, had been observed earlier by C.S. Foote et al. [3] and extended to numerous derivatives by J.M. Conia et al. [4] [5]. and follows a new selection rule, termed syn-preference [1], in the ene addition of 1O2.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19790620318
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  • 5
    Electronic Resource
    Electronic Resource
    β-Cleavage of Bis(homoallylic) Potassium Alkoxides. Preparation of 3-Hydroxypropyl and 4-Hydroxybutyl Propenyl Ketones from γ- and δ-Lactones. Synthesis of (±)-Rose oxide (1987)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 70 (1987), S. 1879-1885 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Starting from γ- and δ-lactones 1-3, a two-step preparation of 3-hydroxypropyl and 4- hydroxybutyl propenyl ketones 10-18 is described, involving as the key step the β-cleavage of the bis(homoallylic) potassium alkoxides 4a-9a. The novel methodology is illustrated by a short synthesis of (±)-rose oxide(20).
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19870700722
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  • 6
    Electronic Resource
    Electronic Resource
    β-Cleavage of Bis(homoallylic) Potassium Alkoxides. Two-Step Preparation of Propenyl Ketones from Carboxylic Esters. Synthesis of ar-Turmerone, α-Damascone, β-Damascone, and β-Damascenone (1987)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 70 (1987), S. 1858-1878 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The transformation of 36 bis(homoallylic) alcohols VII to alkenones IX and X via β-cleavage of their potassium alkoxides VIIa in HMPA has been investigated (cf. Scheme 2). These studies have established an order of β-cleavage for 2-propenyl, 1-methyl-2propenyl, 2-methyl-2-propenyl, 1,1-dimethyl-2propenyl, and benzyl groups in alkoxides 49a-56a and have allowed a comparison between the β-cleavege reaction and the oxy-Cope rearrangement in alkoxides 74a-83a. As illustrative syntheti applications, a two-step preparatio of propenyl ketones 15-42 from carboxylic esters is described, together with syntheses of ar-turmerone (48), α-damascone ((E)-71), β-damascone ((E)-109), and β-damascenone ((E)-111).
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19870700721
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  • 7
    Electronic Resource
    Electronic Resource
    Ionisation Energies and the Electronic Structures of the N-oxides of Azanaphthalenes and azaanthracenes (1975)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 58 (1975), S. 1641-1648 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The HeI photoelectron spectra of the N-oxides of the azanaphthalenes 1-5 and of the azaanthracenes 6, 7 were ascertained. The inferred ionisation energies, and the assignments of the spectra, are presented and are discussed in respect to the electronic structures of the N-oxides and the spectra of the azaderivatives. The data supports the description of the electronic structures of the basic heterocyclic N-oxides based on PPP SCF calculations and the electronic abrosption spectroscopy.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19750580619
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  • 8
    Electronic Resource
    Electronic Resource
    Spectres photoélectroniques He(I) et He(II) du benzo[b]sélénophène et du benzo[b]tellurophène (1975)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 58 (1975), S. 2646-2650 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: He(I) and He(II) photoelectron spectra of benzo[b]selenophene and benzo[b]telluropheneThe photoelectron spectra of benzo[b]selenophene (2) and benzo[b]tellurophene (1) have been recorded with He(I) and He(II) radiation and been compared to those of benzo[b]thiophene (3), benzo[b]furan (4), indole (5) and indene (6). The first four bands are correlated with π-orbitals, of which the highest occupied one is strongly localized on the heteroatom in the case of 1. The results are in agreement with semi-empirical PPP-calculations.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19750580848
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  • 9
    Electronic Resource
    Electronic Resource
    Angular- and Energy-Dependence of Band Intensities in the Photoelectron Spectra of Phosphabenzene and Arsabenzene (1976)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 59 (1976), S. 1944-1948 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The He(II) photoelectron spectra of phosphabenzene 2 and arsabenzene 3 yield additional ionization energies in the region 17 to 20 eV. The relative intensity changes of the first three bands, compared to their relative intensities in the He(I) spectra, provide support for the previously proposed sequence of states ˜X = 2B1, ˜A = 2A2, ˜B = 2A1. This and the angular dependence of the photoelectron band intensities in the spectra of 2 and 3 is in excellent agreement with the theoretical predictions made by von Niessen, Diercksen & Cederbaum [9].
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19760590607
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  • 10
    Electronic Resource
    Electronic Resource
    Preference for Syn Ene Additions of 1O2 to Trisubstituted, Acyclic Olefins (1978)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 61 (1978), S. 2777-2783 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Dye-sensitized photooxygenations of 3 pairs of (E)/(Z) trisubstituted olefins were studied in order to establish the partitioning between the 3 possible ene additions. The (E)-isomers underwent only the 2 ene additions (〉95%) involving H-atom abstractions at the same, disubstituted side of the olefins, termed syn ene additions, with almost equal ease. The (Z)-isomers underwent mainly (85-90%) the syn ene additions, with the ones leading to the tertiary hydroperoxides distinctly favoured, and some (10-15%)ene additions at the monosubstituted side of the olefin, termed anti ene addition.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19780610805
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