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  • 1
    ISSN: 1432-1106
    Keywords: Child development ; Postural control ; Long-loop reflexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Short (SL), medium (ML), and long (LL) latency EMG responses of leg muscles were recorded after perturbation of stance by means of a sudden toe-up tilt of a movable platform. 56 healthy children varying in age between 14 months and 15 years were investigated. All three responses were present when children were able to stand on the recording platform. The SL-response in the triceps surae muscle, which corresponds to the mono- and oligo-synaptic spinal stretch reflex, showed a decreasing latency up to the age of 5 years. This reflects the increasing peripheral nerve conduction velocity. The ML-response in the triceps surae muscle, which as the SL-response has no stabilizing effect in this experiment, showed somewhat delayed maturational changes. The LL-response in the relaxed anterior tibial muscle helps to restore upright posture even in the youngest children. Its maturational changes in terms of latency by far exceed the range that can be explained by the increase of peripheral and spinal conduction velocities. Its mechanisms of maturation, besides the biophysical optimalization of a polysynaptic network, may include learning in terms of selecting the shortest pathways by way of synaptic potentiation within structures involved in the supposedly transcortical pathway of the LL-response. Qualitative observations made during the trials showed that the pattern of postural adaptation changed with age, suggesting the development of additional intersegmental mechanisms.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 73 (1988), S. 167-180 
    ISSN: 1432-1106
    Keywords: Cerebellum ; Movement control ; Timing ; Movement execution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a previous study (Ivry and Keele, in press), cerebellar patients were found to be impaired on both a motor and a perceptual task which required accurate timing. This report presents case study analyses of seven patients with focal lesions in the cerebellum. The lesions were predominantly in the lateral, hemispheric regions for four of the patients. For the remaining three patients, the lesions were centered near the medial zone of the cerebellum. The clinical evaluation of the patients also was in agreement with the different lesion foci: lateral lesions primarily impaired fine motor coordination, especially apparent in movements with the distal extremities and medial lesions primarily disturbed balance and gait. All of the patients were found to have increased variability in performing rhythmic tapping when tapping with an effector (finger or foot) ipsilateral to the lesion in comparison to their performance with a contralateral effector. Separable estimates of a central timekeeper component and an implementation component were derived from the total variability scores following a model developed by Wing and Kristofferson (1973). This analysis indicated that the poor performance of patients with lateral lesions can be attributed to a deficit in the central timing process. In contrast, patients with medial lesions are able to accurately determine when to make a response, but are unable to implement the response at the desired time. A similar dissociation between the lateral and medial regions has been observed on a time perception task in patients with cerebellar atrophy. It is concluded that the lateral regions of the cerebellum are critical for the accurate functioning of an internal timing system.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1106
    Keywords: Motion perception ; Spatial frequency ; Aubert-Fleischl phenomenon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Apparent velocities of moving visual stimuli are known to be different depending on whether the subject pursues the stimulus (efferently controlled motion perception) or whether the eye is stationary and the image moves across the retina (afferent motion perception). Afferent motion perception of a periodic pattern or a moving single object causes overestimation of velocity (magnitude estimations) as compared to smooth pursuit. This socalled Aubert-Fleischl phenomenon is shown to depend on local temporal frequency stimulation on the retina caused by the repetitive passage of contrast borders of the moving periodic pattern. This is evidenced by the fact that for a given stimulus speed the amount of overestimation is a function of the spatial frequency of the pattern (or the angular subtend of a single moving object) and that the Aubert-Fleischl phenomenon is not observed if a single edge moves. Background characteristics seem not to influence the apparent velocity during smooth pursuit.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 234 (1987), S. 396-400 
    ISSN: 1432-1459
    Keywords: Subclavian steal syndrome ; Vertebrobasilar insufficiency ; Doppler sonography ; Atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Continuous-wave (CW) Doppler sonography has proved to be a reliable tool both to detect subclavian stenosis or occulusion and to detect reversal of blood flow in the vertebral artery. This method is entirely atraumatic and in contrast to angiography allows investigation of asymptomatic patients and provides more representative data for epidemiological studies. The incidence of subclavian stenosis or occlusion was 1.15% among the 23,500 patients examined in our department between 1978 and 1985. Of the 272 patients with unilateral or bilateral subclavian stenosis or occlusion, 54% were asymptomatic with no subjective complaints and were normal upon neurological examination; 29% reported vertebrobasilar transient ischaemic attacks (TIAs), with or without concomitant TIAs or infarction in the vascular territory of the carotid arteries; and 17% complained of symptoms exclusively referring to the region of carotid blood supply. Reversal of blood flow in the ipsilateral vertebral artery was detected in 152 patients (56%). The incidence of neurological symptoms within this group was double that found in patients without steal. None of the patients suffered from permanent vertebrobasilar damage. In most cases, subclavian artery disease was due to atherosclerosis. For 13 patients an inflammatory, iatrogenic, traumatic, or congenital aetiology could be assumed. The marked preponderance of left-sided subclavian stenosis or occlusion, reported by others, could be confirmed among our patients, but was less pronounced for tight stenoses than for occlusions. Mild-to-moderate subclavian stenoses were about equally distributed on each side.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 235 (1988), S. 475-484 
    ISSN: 1432-1459
    Keywords: Tremor recording ; Parkinson's disease ; Resting tremor ; Diurnal variations ; Treatment effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new method of prolonged recording of EMG provides a good estimate of spontaneous and induced diurnal variations in resting tremor in Parkinson's disease. It provides a record and a measure of the effects of treatment. Tremor intensity shows considerable variations even over short periods of time. Therefore short-term measurements of tremor are unhelpful. Long-term recordings agree better with the patient's assessment than with the clinical rating score. Repeated recordings over a similar 10-h period on 3 consecutive days in one patient showed fairly constant measures of occurrence and intensity of tremor. In contrast to accelerometer measurements of tremor, artefacts caused by movements and general activity of the patient do not materially interfere with tremor evaluation using surface EMG.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 235 (1987), S. 122-124 
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Hodgkin's disease ; MRI ; Anti-Purkinje-cell antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of paraneoplastic cerebellar degeneration (PCD) associated with Hodgkin's disease is presented. The features that make this case particularly interesting are the simultaneous occurrence of PCD with a relapse of Hodgkin's disease, which has been present for 17 years, and the arrested progression of cerebellar dysfunction after a subacute onset. Cerebellar atrophy was revealed by computed tomography and magnetic resonance imaging. In contrast to two previously reported cases, anti-Purkinje-cell antibodies were not detected.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1459
    Keywords: Alcoholic neuropathy ; Alcoholic cerebellar degeneration ; Posturography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 78 chronic alcoholics were examined neurologically as well as by electroneurography, myography and posturography. Clinical signs of peripheral neuropathy were detected in 45% of these patients, with electromyographic and neurographic abnormality in 67% and 55% respectively. Clinical signs of cerebellar ataxia were found in 33% of our patients, whereas posturographic measurements of increased sway were recorded in 69%. The posturographic characteristics of cerebellar anterior lobe atrophy were observed in two-thirds of the latter patients. The severity of cerebellar-ataxia did not correlate with the degree of neuropathy. This lack of correlation is interpreted as an indication of different pathogenetic mechanisms acting on peripheral nerves and cerebellum.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1459
    Keywords: Posturography ; Paraneoplastic cerebellar degeneration ; Cortical cerebellar atrophy ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological examination and posturography showed cerebellar signs in 13 of 50 unselected patients with bronchogenic carcinoma not complicated by other diseases. The occurrence of cerebellar signs did not depend on the histological type of tumour or the extent of tumour spread. Most of the clinically affected patients had mild to pronounced cerebellar atrophy, revealed by CT. The correlation between the amount of CT-confirmed atrophy and the severity of clinical symptoms, however, was poor. Since other reasons for cerebellar dysfunction (e.g. chemotherapy, chronic alcoholism, metastases) were excluded, cerebellar signs were attributed to paraneoplastic cerebellar degeneration or to a consequence of severe neoplastic illness. The high incidence of cerebellar dysfunction in patients with bronchogenic carcinoma confirms the frequent histopathological finding of cortical cerebellar degeneration in malignant disease.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1459
    Keywords: Paraneoplastic cerebellar degeneration ; Anti-Purkinje cell antibodies ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sera from seven patients with bronchogenic carcinoma and cerebellar dysfunction were tested for anti-Purkinje cell antibodies (APCA) by indirect immunofluorescence and indirect immunoperoxidase reaction. Specific APCA as described in paraneoplastic cerebellar degeneration (PCD) were not detected in any of these patients or in control patients. The lack of APCA in patients with bronchogenic carcinoma and their presence in association with ovarian or breast cancer indicate that different pathogenetic mechanisms may play a role in PCD.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1459
    Keywords: Computed tomography ; Cerebellar atrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The severity of cerebellar signs and the degree of cerebellar atrophy depicted by computed tomography (CT) were independently graded in 108 patients with cerebellar disorders. The overall agreement between these independently scaled measures was only 28%. In patients with involvement of the cerebellar hemispheres and anterior lobe, clinical signs tended to be more pronounced than the cerebellar atrophy revealed by CT. The opposite was true for patients with lesions of the caudal vermis. Patients with Friedreich's ataxia had no or only minor CT abnormalities. Close correlation between the degree of infra- and supratentorial atrophy was found only in chronic alcoholics. The poor correlation between changes in cerebellar structure detected by CT and clinical disability suggests the need for caution in CT interpretation.
    Type of Medium: Electronic Resource
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