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  • 1985-1989  (2)
  • 1975-1979  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    THE UPTAKE OF BIOGENIC MONOAMINES BY THE ISOLATED AURICLE OF THE SNAIL (HELIX POMATIA) (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 26 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: —The uptake of [3H]5HT, [3H]dopamine, [3H]noradrenaline and [3H]octopamine into the auricle of Helix pomatia was studied.When tissues were incubated at 25°C in media containing radioactive amines, tissue:medium ratios of about 49:1, 14:1 and 5:1 for 5-HT, dopamine, noradrenaline, and octopamine respectively were obtained after a 20–30 min incubation time. Tissues incubated at 25°C in media containing radioactive amines for 20–30 mins showed that almost all (96%) the radioactivity was present as unchanged [3H]5-HT, [3H]dopamine, [3H]octopamine or [3H]noradrenaline.The high tissue:medium ratios for 5-HT and dopamine, but not for noradrenaline and octopamine, showed saturation kinetics which were dependent upon temperature and sodium ions. From the Lineweaver–Burk plots, two uptake mechanisms for 5-HT at 25°C were resolved; the high affinity uptake process having a Km1 value of 6.0 ± 10−8m and a Vm1 value of 0.115 nmol/g/min while the lower affinity process had a Km2 value of 1.04 ± 10−6m and a Vm2 value of 0.66nmol/g/min. At 0°C a single uptake mechanism for 5-HT occurred which gave a Km value of 5.02 ± 10−8m and a Vm value of 0.0165 nmol/g/min. In the case of dopamine, the Lineweaver–Burk plot at 25°C showed a single uptake process with values for Km and Vm of 1.55 ± 10−7m and 0.086 nmol/g/min respectively. This process did not function at 0°C.The effect of various agents and ions upon the accumulation processes for all amines was also studied, and the data indicate that the same neurons probably accumulate more than one amine type.It is concluded that 5-HT and dopamine uptake in the auricle is a mechanism for inactivating these substances at 25°C and that an uptake mechanism for 5-HT also functions at 0°C. The results are discussed from the point of view of 5-HT's being the cardioexcitatory substance in the snail heart.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb04486.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Estimation of serotonin and its action on oviducts and uteri of some oviparous and viviparous insects (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 118-120 
    Details
    ISSN: 1420-9071
    Keywords: Central nervous system ; insects ; oviduct ; serotonin ; uterus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Serotonin was not found in the oviducts ofBlabera gigantea, Clitumnus extradentatus nor in the uterus ofGlossina, but it is present in the uterus ofBlabera. It is also found in the central nervous system of all three insects. In vitro experiments confirm these data by showing that serotonin increases the contractions of the uterus ofBlabera, but has no effect on the uterus ofGlossina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02005907
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of proctolin on the adenylate and guanylate cyclases in theLocusta brain at various developmental stages (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1287-1288 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Proctolin at concentrations 10−8–10−7 M elevated by 40% brain adenylate cyclase activity of adultLocusta migratoria migratorioides R.F. In moulting individuals, proctolin caused a decrease in brain adenylate cyclase activity, and it proved to be ineffective in the larvae. Proctolin caused only a slight decrease on guanylate cyclase activity of the brain at every developmental stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963960
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Naloxone selectively blocks dopamine response of Br-type neuron inHelix pomatia L. (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 1337-1338 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present study demonstrates that the potent opiate antagonist, naloxone can selectively block the DA induced inhibition of the bursting activity pattern of the RPal or Br-type neuron. The dopamine inhibitory affect can also be blocked by haloperidol, a established dopamine receptor blocker.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01963994
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    A comparison of four techniques for mapping the distribution of serotonin and serotonin-containing neurons in fixed and living ganglia of the snail,Lymnaea (1989)
    Springer
    Journal of neurocytology 18 (1989), S. 193-208 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of serotonin and serotonin-containing neurons was studied in the ganglia of the CNS of the snailLymnaea stagnalis. Results of the application of three different labelling techniques on wholemount preparations were compared with each other and with the serotonin content of the ganglia, measured by high-performance liquid chromatography. Serotonin immunocytochemistry resulted in the highest number of labelled neurons, but the more recently developedin vivo method of 5,6- or 5,7-dihydroxytryptamine-induced pigmentation also proved to be a reliable technique for the visualization of serotonin-containing cell bodies. In comparison with these two techniques, the glyoxylic acid fluorescence method appeared to be less sensitive. The distribution and number of serotonin-containing neurons and biochemically measured serotonin in specific ganglia showed a close correlation. By combining the results of the three labelling techniques, a detailed map of serotonin-containing neurons was constructed, and this was compared with maps of identified neurons prepared from earlier electrophysiological studies. Previously described serotonergic neurons were consistently found, as well as several new serotonin-containirig cell types in the cerebral, visceral and parietal ganglia. A network of serotonin-containing inter- and intraganglionic axon tracts, and thin serotonergic fibres in the perineurium were also demonstrated. Thisin vivo andin vitro identification of serotonin-containing neurons will facilitate further neurophysiological analysis of serotonergic neural mechanisms inLymnaea.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01206662
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    Paper (German National Licenses)
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