ISSN:
1432-1912
Keywords:
Gallopamil
;
Brain energy metabolism
;
Calcium
;
Isolated perfused rat brain
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The isolated perfused rat brain was used to demonstrate an effect of gallopamil on energy metabolism affected by ischemia. After a perfusion period of 30 min and 10 min of ischemia the isolated brain preparation was reperfused. From the onset of perfusion onwards, gallopamil (1 or 10 μmol/l) was present in the medium. The higher concentration of gallopamil accelerated significantly the restoration of the high-energy phosphates in the recovery stage: after 2 min of recirculation the ATP and the creatine-P levels were higher and the AMP level was lower in cortical tissue of drug-treated brains than in untreated controls. These results suggest that gallopamil protected brain energy metabolism against ischemic damage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00496381
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