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  • 1985-1989  (1)
  • 1970-1974  (1)
  • 1920-1924
  • 5-Hydroxytryptophan  (1)
  • Cardiac apex  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 10 (1988), S. 151-160 
    ISSN: 1279-8517
    Keywords: Apex of the heart ; Cardiac apex ; Apical arteries ; Apical blood supply ; Anatomical apex ; Geometric apex of the heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Cette étude comporte un essai de définition de l'apex du cœur et une présentation d'une classification en 3 types: l'apex « anatomique », dont la base est délimitée par l'incisure de l'apex du cœur, l'apex « anatomique élargi », occupant le double volume du précédent et l'apex « géométrique », occupant le tiers distal des ventricules. La vascularisation de ces 3 types d'apex cardiaque par les branches superficielles des artères coronaires, est précisé. Ce travail a été effectué sur 81 cœurs normaux (56 hommes et 25 femmes) dont 60 Caucasiens et 21 non Caucasiens. Les artères ont été injectées avec un mélange de gélatine colorée et de substance radio-opaque. Le nombre des rameaux artériels va en décroissant depuis le type géométrique (le plus volumineux) jusqu'à l'apex anatomique (le plus petit): 27 sont retrouvés à la surface de l'apex géométrique, 14 à la surface de l'apex anatomique élargi et 7 seulement au niveau de l'apex anatomique. Des différences selon le sexe ont été observées au niveau du rameau postérieur du ventricule gauche qui est retrouvé plus souvent chez les hommes que chez les femmes pour les apex anatomiques élargis. Pour les apex géométriques, 3 branches sont également plus fréquentes chez les femmes: le rameau antérieur et inférieur du ventricule gauche, les branches I et IV du rameau postérieur et latéral du ventricule gauche.
    Notes: Summary The cardiac apex was defined and 3 types were presented: the anatomical apex, the base of which was established at the incisura apicis cordis; the amplified anatomical apex, twice the volume of the preceding; and the geometric apex, the distal third of the ventricles. These types of cardiac apex were studied in connection with the superficial branches of the coronary series at their level. The investigation was conducted on 81 normal hearts (56 males and 25 females) of 60 Caucasian and 21 non-Caucasian individuals. The arteries were injected with colored gelatine mixed with a radiopaque substance. The number of branches decreased from the geometric (the largest type) to the anatomical apex (the smallest): 27 on the surface of the geometric apex, 14 on the surface of the amplified anatomical apex, and 7 on the surface of the anatomical apex. The sternocostal aspect had a higher number of superficial branches than the diaphragmatic aspect in all types of cardiac apex. Sexual differences were found in the incidence of the r posterior ventriculi sinistri intermedius on the amplified anatomical apex as it was more frequent in females than in males. In the geometric apex there were 3 branches also more frequent in females: r anterior ventriculi sinistri inferior, r posterior ventriculi sinistri lateralis I, and r posterior ventriculi sinistri lateralis IV.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1912
    Keywords: DOPA ; 5-Hydroxytryptophan ; Tyrosine Hydroxylase in Rat Brain ; Tryptophan Hydrolyxase in Rat Brain ; NSD 1015 (3-hydroxybenzylhydrazine)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary DOPA and 5-HTP accumulated in vivo in rat brain after decarboxylase inhibition with NSD 1015 (3-hydroxybenzylhydrazine). This accumulation was linear for the first 30 min and occurred in several brain regions over a wide range of NSD 1015 doses. After a peripheral decarboxylase inhibitor much less, if any, DOPA or 5-HTP accumulated in the brain. The accumulation of DOPA was prevented by H 44/68 (methylester of α-methyl para-tyrosine), a tyrosine hydroxylase inhibitor. DOPA, which accumulated before H 44/68 was given, appeared stable for at least 20 min. There were no significant changes in the levels of NA, DA, 5-HT or tryptophan shortly after NSD 1015 administration, but a rise in tyrosine was noted. Increased brain tyrosine after l-tyrosine administration did not alter the DOPA accumulation, however. These data as well as the distribution of the accumulated amino acids suggest that the accumulation of DOPA and 5-HTP after decarboxylase inhibition occurs intraneuronally, that the decarboxylase enzyme is completely inhibited, and that the accumulated products are not appreciably metabolized or transported from the region studied. Amine synthesis rates and rate constants were calculated from the data and compare well with similar values determined by other methods. Thus this accumulation appears to be a reliable measure of the in vivo hydroxylation of tyrosine and tryptophan.
    Type of Medium: Electronic Resource
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