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  • 1
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Chronic ingestion of bile-acid sequestrants has been shown to decrease the serum cholesterol concentration and coronary events in hypercholesterolaemic patients. To develop improved sequestrants, a rapid, convenient method for testing the bile-acid binding efficacy of sequestrants is needed. Serum bile-acid concentrations could be used to detect bile-acid binding by an administered sequestrant, since the serum bile-acid concentration is determined largely by the rate of intestinal absorption in healthy individuals. To test this, serum bile-acid concentrations were measured at frequent intervals over 24 h in five otherwise healthy hypercholesterolaemic subjects during the ingestion of three standard meals, with or without the addition of 5 g colestipol granules administered 30 min before each meal.Total serum bile-acid concentration was measured with a previously reported bioluminescent enzymic assay, that uses a 3α-hydroxysteroid dehydrogenase, an oxido-reductase, and a bacterial luciferase co-immobilized on to Sepharose beads. Bile acids in 1 ml of serum were isolated by solid-phase extraction chromatography with reversed-phase C18 cartridges.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 231 (1970), S. 279-292 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Deuteron scattering experiments were performed at the Erlangen Tandem Van de Graaff accelerator using a counter telescop with surface barrier detectors in conjunction with a PDP 7 on line computer. Elastic and inelastic differential cross sections were obtained from deuteron scattering from25Mg and27Al at excitation energies up to 3.4 MeV. Bombarding energy was 10.1 MeV. Angular distributions and integrated cross sections are discussed using collective models. It is shown, that the levels of25Mg can be well described by the rotational model (strong coupling model). The results for27Al allow a good description by the core excitation model (weak coupling model).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 242 (1971), S. 308-319 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract For the reaction40Ca(d,α)38K differential cross sections for the excitation of the low lying states in38K have been measured at bombarding energies between 5 and 10 MeV. Total cross sections have been calculated using the statistical theory. It was found, that in the whole energy region the isotropic background of the angular distributions gives a good estimation of the compound contribution to the reaction cross section.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 260 (1973), S. 35-45 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Differential cross sections for 10 MeV deuterons, elastically scattered from24,26Mg and28,30Si have been measured. The scattering data have been analysed systematically in the framework of the optical model. It was found, that an uniform set of parameters, which is able to reproduce reasonably the angular distributions for the four nuclei, does not exist. Both the Mg distributions as well as both the Si distributions, however, can be described well with one set of parameters, respectively.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The elastic and inelastic α-scattering cross section has been measured for the nuclei26Mg,28,30Si at 15 bombarding energies between 15.0 and 16.4 MeV. The energy averaged scattering cross sections can be described by an incoherent sum of contributions from direct and compound reactions. The direct reaction part has been calculated by the optical model or DWBA, the compound reaction part by a simple Hauser-Feshbach formula. From the analyses deformation parameters and spin cut-off parameters are obtained.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 231 (1970), S. 177-192 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A very sensitive microphone suitable for acoustic measurements in liquid helium is described. With the use of it both, the pressure amplitude of second sound and the amplitude of first sound radiated from the second sound transmitter (carbon layer heater) can be detected. By a special extension of the reciprocity theory the first sound pressure response of the microphone and the second sound transmitter response can be measured. The measured pressure signals of first and second sound are compared with the results of the two-fluid theory.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1342-1343 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Diazoacetylcholinebromide was used for affinity labelling of the cholinergic receptors of endplates in the mouse diaphragm. Under irradiation by light (Hg-high-pressure-lamp), irreversible depolarizing block of neuromuscular transmission developed. Acetylcholinesterase was influenced only by much higher concentrations, which demonstrates different localizations of the active enzyme center and the cholinergic receptor.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 98 (1988), S. 408-416 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ascutney Mountain complex of eastern Vermont, USA, is a composite epizonal pluton of genetically related gabbro to granite intrusives. Nd isotopic data are reported for mafic rocks, granites, and nearby country rock. The parental mafic magma producing the complex 122 m.y. ago had 87Sr/86Sr=0.7039, 143Nd/144Nd=0.512678 (ɛ Nd=+3.8) and δ 18O=6.1‰, indicating a mantle source with time-integrated lithophile element depletion. Uniform initial radiogenic isotope ratios for granites, which are undistinguishable from those for the most primitive gabbro, suggest that the granite magma evolved from the mafic magma without crustal contamination and that the increase in δ 18O, to about 7.8‰, is the result of fractional crystallization. Mafic rocks show a large range in initial 143Nd/144Nd ratio, from about 0.51267 to 0.51236 (ɛ Nd= +3.7 to −2.5), which is correlated with elevated 87Sr/86Sr ratios and δ 18O. These data substantiate the production of mafic lithologies by fractional crystallization of the parental magma accompanied by assimilation of up to about 50% crust. The local country rocks include gneiss and schist and assimilation involved representatives of both rock types. The isotopic and chemical relationships preclude derivation from a single batch of magma undergoing contamination and indicate that a large magma body at depth evolved largely by fractionation with batches of melt issued from this chamber being variably contaminated at higher levels or at the level of emplacement. The Precambrian gneisses of the Chester dome and overlying lower Paleozoic schists have essentially identical Nd isotope systematics which suggest a crustal formation age of about 1.6. b.y. The parental sediments for the schists were apparently derived from a protolith similar to the gneissic basement without appreciable Sm/Nd fractionation.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Contributions to mineralogy and petrology 97 (1987), S. 31-42 
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract The Ivrea zone represents a tilted cross section through deep continental crust. Sm-Nd isotopic data for peridotites from Baldissero and Balmuccia and for a suite of gabbros from the mafic formation adjacent to the Balmuccia peridotite provide evidence for an event of partial melting 607±19 Ma ago in an extended mantle source with ɛ 607 Nd =+0.4±0.3. The peridotites are interpreted as the corresponding melt residue, the lower part of the mafic formation as the complementary melts which underwent further differentiation immediately after extraction. The Finero body represents a complex with layers of phlogopite peridotite, hornblende peridotite, and amphibole-rich gabbro. The isotopic signatures fall into two groups: (1) highly radiogenic Nd and low-radiogenic Sr characterize the phlogopite-free, amphibole-rich rocks, whereas (2) low-radiogenic Nd and highly radiogenic Sr is found in ultramafics affected by “phlogopite metasomatism”. Phlogopite metasomatism in the Ivrea zone is dated by a Rb-Sr whole rock isochron yielding 293±13 Ma. It was fed by K-rich fluids which were probably derived from metasediments. The high initial ɛ 293 Nd value of about +7.5 for phlogopite-free samples indicates a high time-integrated Sm/Nd ratio in the Finero protolith 293 Ma ago. Sm-Nd analyses of metapelites from the paragneiss series yield Proterozoic “crustal residence ages” of 1.2 to 1.8 Ga. Internal Sm-Nd isochrons for three garnetiferous rocks show that closure of garnet at temperatures around 600° C or even lower occurred about 250 Ma ago.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0967
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Apparent crustal residence ages indicated by Nd model age data for metamorphic rocks, sediments and granitoids of the Hercynian Fold Belt of Europe vary from 1.3 Ga to 3.0 Ga, but are mainly in the range 1.4–1.7 Ga. 2 Ga basement inliers have been documented previously in northern Spain and islands off northwestern France but, in addition to these, old (∼2–3 Ga) model ages are found along the southern margin of the fold belt. These do not identify old inliers but are interpreted to represent Archeanearly Proterozoic crustal components recycled from a southern source. The Nd data, when considered together with the surface geology and recent single-grain zircon ion microprobe data, argue against a binary mixing of Archean components with new Palaeozoic crustal additions to generate the main 1.4–1.7 Ga model age population. Hercynian Europe comprise mainly recycled Proterozoic components although significant new Palaeozoic additions as well as Archean contributions are indicated. Nd and Sr isotopic data together with previous chemical and petrographic observations allow the recognition of a northern belt of continent margin I-type granitoids grading southwards to inner continent S-type plutons in the eastern half of the fold belt. This felsic plutonic association is used to infer a Hercynian plate configuration involving the attachment of the fold belt to a southern parent cratonic block that the model age data suggest may be of early Proterozoic-Archean age.
    Type of Medium: Electronic Resource
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