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  • 1
    Electronic Resource
    Electronic Resource
    Large non-homology in heteroduplex DNA is processed differently than single base pair mismatches (1987)
    Springer
    Molecular genetics and genomics 206 (1987), S. 181-184 
    Details
    ISSN: 1617-4623
    Keywords: Escherichia coli ; Bacteriophage λ ; DNA loops ; DNA repair ; Gene conversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Unmethylated DNA heteroduplexes with a large single stranded loop in one strand have been prepared from separated strands of DNA from two different strains of bacteriophage λ, one of which has a ∼800 base pair IS1 insertion in the cI gene. The results of transfections with these heteroduplexes into wild-type and mismatch repair deficient bacteria indicate that such large non-homologies are not repaired by the Escherichia coli mismatch repair system. However, the results do suggest that some process can act to repair such large non-homologies in heteroduplex DNA. Transfections of a series of recombination and excision repair deficient mutants suggest that known excision or recombination repair systems of E. coli are not responsible for the repair. Repair of large non-homologies may play a role in gene conversion involving large insertion or deletion mutations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326556
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sleep and benzodiazepine receptor sub-types (1987)
    Springer
    Journal of neural transmission 70 (1987), S. 329-336 
    Details
    ISSN: 1435-1463
    Keywords: Sleep ; benzodiazepines ; CL 218,872
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary CL 218,872, which preferentially binds to benzodiazepine (BZ) type 1 receptors, and flurazepam, which is thought to bind to both types 1 and 2, were given alone and in combination to rats. CL 218,872 had little effect on sleep latency, but significantly increased total sleep time. As expected, flurazepam both shortened sleep latency and prolonged total sleep. Pretreatment with CL 218,872 had no effect on these alterations in sleep induced by flurazepam. The implications for possible significance of sub-typing of BZ receptors are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01253607
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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