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Sleep and benzodiazepine receptor sub-types (1987)

Mendelson, W. B. ; Martin, J. V. ; Perils, M. ; [et al.]

Springer

Journal of neural transmission 70 (1987), S. 329-336

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ISSN: 1435-1463

Keywords: Sleep ; benzodiazepines ; CL 218,872

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary CL 218,872, which preferentially binds to benzodiazepine (BZ) type 1 receptors, and flurazepam, which is thought to bind to both types 1 and 2, were given alone and in combination to rats. CL 218,872 had little effect on sleep latency, but significantly increased total sleep time. As expected, flurazepam both shortened sleep latency and prolonged total sleep. Pretreatment with CL 218,872 had no effect on these alterations in sleep induced by flurazepam. The implications for possible significance of sub-typing of BZ receptors are discussed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01253607

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