ISSN:
0020-7608
Keywords:
Computational Chemistry and Molecular Modeling
;
Atomic, Molecular and Optical Physics
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A class of thromboxane antagonists exists where the prostaglandin side chain containing the C16 hydroxyl moiety is replaced by a phenyl ring, and the bridged six-membered pyranose moiety by cyclohexane, pyranose and dioxane ring systems. Analysis of antagonist potency data in terms of a binding constant model previously used for membrane bound receptor-drug interactions shows that the major patterns of antagonist potency are governed as much by axial/equatorial conformer preference of the phenyl moiety and its orientation as by electrostatic effects of the aliphatic ring oxygen atoms. The conformational restriction of the two substituted side chains of the σ-bonded 6-membered ring is shown to be a primary requirement for binding to thromboxane receptors, and a quantitative separation of electrostatic and conformational components in the potency data is attempted.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/qua.560340708
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