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  • 1985-1989  (2)
  • 1970-1974  (1)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Identification and Characterisation of 5-Hydroxytryptamine3 Recognition Sites in Human Brain Tissue (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 53 (1989), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: [3H]Zacopride displayed regional saturable specific binding to homogenates of human brain tissues, as defined by the inclusion of BRL43694 [endo-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-l-methylindazole-3-carboxamide] in the incubation media. Scatchard analysis of the saturation data obtained from amygdaloid and hippocampal tissues identified the binding as being of high affinity and to a homogeneous population of binding sites (KD= 2.64 ± 0.75 and 2.93 ± 0.41 nmol/L and Bmax= 55 ± 7 and 44 ± 9 fmol/ mg of protein in the amygdala and hippocampus, respectively). 5-Hydroxytryptamine3 (5-HT3) receptor agonists and antagonists competed for the [3H]zacopride binding site, competing with up to 40% of total binding with a similar rank order of affinity in both tissues; agents acting on various other neurotransmitter receptors failed to inhibit binding. Kinetic data revealed a fast association that was fully reversible (k+1= 6.61 × 105 and 7.65 × 105/mol/L/s and k-1= 3.68 × 10−3 and 3.45 × 10−3/s in the amygdala and hippocampus, respectively). It is concluded that [3H]zacopride selectively labels with high affinity 5-HT3 recognition sites in human amygdala and hippocampus and, if these binding domains represent 5-HT3 receptors, may provide the opportunity for 5-HT3 receptor antagonists to modify 5-HT function in the human brain
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1989.tb09244.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    5-HT 3 receptors mediate inhibition of acetylcholine release in cortical tissue (1989)
    [s.l.] : Nature Publishing Group
    Nature 338 (1989), S. 762-763 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Release of [3H]acetylcholine from rat entorhinal cortex pre-loaded with [3H] choline was stimulated by potassium. Previous studies have shown that the tritium released is [3H]acetylcholine, and that the release is calcium-dependent13. 5-HT (2 p,M) or the selective 5-HT3 receptor agonist, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/338762a0
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Toxicity of new pyrethroid insecticide (1974)
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 711-711 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Given as solutions in glycerol formal by the intravenous route, the lethal dose of NRDC 156 was 6 to 8 mg kg^1 and of NRDC 161, 2 to 2.5 mg kg'"1. Orally, as solutions in arachis oil, an LDso could not be computed, but the rats showed severe toxic effects, with some deaths in the dose range 80 to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/248711a0
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    Paper (German National Licenses)
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