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  • 1
    Electronic Resource
    Electronic Resource
    Dual dielectric silicon metal-oxide-semiconductor field-effect transistors as radiation sensors (1989)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 65 (1989), S. 1972-1976 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new design for radiation-sensing field-effect transistors (RADFETs) is presented, involving the use of very thick silicon nitride layers deposited on top of a high-quality thermal silicon dioxide. In contrast to previous RADFET fabrication procedures, no attempt was made to introduce hole traps into the thermal oxide. Instead the trapping layer at the nitride oxide interface was used to store the positive charge which forms the basis for operation of the RADFET. Data is presented which shows hole transport in the thermal oxide. Models explaining the field dependence of the response and the saturation behavior of the dual dielectric device are given. These RADFETs are more stable than any previously described in the literature and have a sensitivity of 86 μV/rad dose at room temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.342887
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  • 2
    Electronic Resource
    Electronic Resource
    TMX-U computer system in evolution (1986)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 1880-1882 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Over the past three years, the total TMX-U diagnostic data base has grown to exceed 10 Mbytes from over 1300 channels; roughly triple the originally designed size. This acquisition and processing load has resulted in an experiment repetition rate exceeding 10 min per shot using the five original Hewlett–Packard HP-1000 computers with their shared disks. Our new diagnostics tend to be multichannel instruments, which, in our environment, can be more easily managed using local computers. For this purpose, we are using HP series 9000 computers for instrument control, data acquisition, and analysis. Fourteen such systems are operational with processed format output exchanged via a shared resource manager. We are presently implementing the necessary hardware and software changes to create a local area network allowing us to combine the data from these systems with our main data archive. The expansion of our diagnostic system using the parallel acquisition and processing concept allows us to increase our data base with a minimum of impact on the experimental repetition rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1139159
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  • 3
    Electronic Resource
    Electronic Resource
    Database tools for enhanced analysis of TMX-U data (1986)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 57 (1986), S. 1929-1931 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A commercial database software package has been used to create several databases and tools that assist and enhance the ability of experimental physicists to analyze data from the Tandem Mirror Experiment-Upgrade (TMX-U) experiment. This software runs on a DEC-20 computer in M-Divisions's User Service Center at Lawrence Livermore National Laboratory (LLNL), where data can be analyzed off line from the main TMX-U acquisition computers. When combined with interactive data analysis programs, these tools provide the capability to do batch-style processing or interactive data analysis on the computers in the USC or the supercomputers of the National Magnetic Fusion Energy Computer Center (NMFECC) in addition to the normal processing done by the TMX-U acquisition system. One database tool provides highly reduced data for searching and correlation analysis of several diagnostic signals within a single shot or over many shots. A second database tool provides retrieval and storage of unreduced data for use in detailed analysis of one or more diagnostic signals. We will show how these database tools form the core of an evolving off-line data analysis environment on the USC computers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1138799
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  • 4
    Electronic Resource
    Electronic Resource
    Omeprazole (20 mg o.m.) versus ranitidine (150 mg b.d.) in duodenal ulcer healing and pain relief (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 3 (1989), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The object of this double-blind, multicentre study was to compare duodenal ulcer healing rates after 2 and 4 weeks of treatment with either 20 mg omeprazole o.m. or 150 mg ranitidine b.d. One hundred and eighty-one patients were randomized: 91 received omeprazole and 90 received ranitidine.In a per protocol analysis at 2 weeks, 63% of the patients were healed on omeprazole and 65% of the patients were healed on ranitidine (N.S.); at 4 weeks 91% were healed in the omeprazole group and 96% were healed in the ranitidine group. There were no differences in ulcer symptom relief between the two groups. There were no significant changes in laboratory values in either of the groups. Adverse events were few and mainly mild and transient.We conclude that both omeprazole (20 mg o.m.) and ranitidine (150 mg b.d.) result in rapid, ulcer healing rates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.1989.tb00235.x
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  • 5
    Electronic Resource
    Electronic Resource
    Observations on rock boring by Alpheus saxidomus (Crustacea: Alpheidae) (1985)
    Springer
    Marine biology 89 (1985), S. 213-219 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract This study describes some aspects of the distribution, ecology, and rock boring behaviour of the shrimp Alpheus saxidomus Holthuis from the Pacific coast of Costa Rica. This species has a typical hammer-shaped dactylus on the first right pereiopod of females and males that shows tracks of abrasion at the hammer-head. Structural analysis of this hammer-dactylus proved that it is suited for the mechanical treatment of rocks. The very thick and calcified cuticle of the hammer is mostly formed by the sclerotinized, hard exocuticle, which has abundant pore canals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00392891
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  • 6
    Electronic Resource
    Electronic Resource
    Morphologie und Häufigkeit der Calcinose in den Beinvenen alternder Menschen (1969)
    Springer
    Virchows Archiv 348 (1969), S. 155-163 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit der abgewandelten v. Kossa-Methode ließen sich Kalkablagerungen in der Vena femoralis und Vena poplitea von 30 männlichen Verstorbenen im Alter von 63–88 Jahren in allen Fällen makroskopisch darstellen. Die Kalkablagerungen traten in Form von unterschiedlich großen, grau-schwarzen Flecken, Feldern und Streifen auf. In 5 Fällen nahmen sie über 1/4 der gesamten Venenwand ein. Die Kalkablagerungen fanden sich vorwiegend unmittelbar distal von Klappenansätzen, unterhalb von Klappenkommissuren, an der Venenwand der Klappensinus, proximal von Mündungen der Seitenäste und mitunter auch um diese Mündungen herum. Häufig lagen sie jedoch auch an der übrigen Veneninnenwand vor. Der mit der begleitenden Arterie verwachsene Streifen der Venenwand blieb dagegen zumeist frei von Kalk. Mikroadiographisch und histologisch handelte es sich um staubförmige und feinkörnige Kalkniederschläge, die ganz überwiegend in der verdickten Venenintima auftraten. In der Hälfte aller Fälle fanden sich inmitten von feinkörnig inkrustierten Intimapartien vereinzelte oder multiple gröbere Kalkschollen. Das untersuchte femoro-popliteale Segment stellt vermutlich den häufigsten Sitz ausgeprägter Calcinose-Formen im Venensystem alternder Menschen dar.
    Notes: Summary Calcifications of the femoral and popliteal veins were demonstrated grossly by a modified von Kossa technique and found in all thirty 63–88 year old male subjects. The calcifications appeared on the inside of veins as grayish or black spots, or as fields or broader stripes. In 5 subjects more than 1/4 of the intimal surface was occupied by the calcified areas. The calcifications were predominantly localized just below the valves and their commissures, in the sinus, at the entires of the tributaries, and proximal to them. The sector of vein that adhered to the artery remained, as a rule, free of calcific deposits. Microradiographically and microscopically the calcifications appeared as fine granular deposits within the markedly thickened intima. In one half of all cases, calcific plaques were found in the vein microradiographs. The femoral and popliteal veins represent presumably the most common site of the pronounced calcifications in the human venous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544322
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  • 7
    Electronic Resource
    Electronic Resource
    Verkalkungsformen der inneren elastischen Membran der Beinarterien und ihre Bedeutung für die Mediaverkalkung (1967)
    Springer
    Virchows Archiv 342 (1967), S. 361-373 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mikroradiographische und histologische Untersuchungen an Flachschnitten der Innenwand der Beinarterien in 30 FÄllen (2–49 Jahre) ergaben als Frühform der Mineralisation des Arterienrohres eine bandförmige Verkalkung der inneren elastischen Membran an den Begrenzungen ihrer vorgebildeten, vorwiegend zirkulÄr orientierten Spalten. Diese Form der Verkalkung (paarweise verlaufende „KalkbÄnder“) fand sich an der A. femoralis und A. poplitea regelmÄ\ig bereits in der 2. Lebensdekade. Mit Abschlu\ des Körperwachstums erreichen die KalkbÄnder hÄufig eine erhebliche Ausbreitung. Durch Verbreiterung und Konfluenz der KalkbÄnder können „Kalkfolien“ entstehen, die streckenweise die gesamte innere elastische Membran erfassen. An der Mediaseite der KalkbÄnder erscheinen frühzeitig körnige Kalkablagerungen („Kalkkörner“). Durch Zusammenflu\ der Kalkkörner entstehen im Bereich der BÄnder zunÄchst kleinere zirkulÄr orientierte Kalkspangen, die sich in die darunter liegende Media ausbreiten. Ihre weitere Volumenzunahme und Konfluenz führt zur Ausbildung gröberer, ringförmiger Kalkspangen. Das für die fortgeschrittene Mediaverkalkung charakteristische Erscheinungsbild wird somit auch durch früh entstehende zirkulÄre KalkbÄnder mitbestimmt, die sich als Leitschienen bzw. Induktoren der nachfolgenden gröberen Kalkablagerungen erweisen.
    Notes: Summary Microradiographic and microscopic studies of tangential sections from the inner wall of the arteries of the lower limb reveal an early band-like calcification of the internal elastic membrane around the margins of its preexisting circular split-like openings. This type of calcification (pairs of circularly oriented calcific bands) is regularly found in the A. femoralis and A. poplitea in the second decade. As body-growth ceases, the calcific bands in these arteries become wide-spread. Later, widening and confluence of calcific bands occurs and sometimes leads to sheet-like mineralisation of internal elastic membrane. On the medial aspect of the calcific bands grain-like calcific deposits develop early. Subsequently they become confluent and form larger incrustations which follow the course of the calcific bands. Thus the development of ring-like calcific deposits which are typical for the later stages of Mönckeberg sclerosis depends partly on the earlier stages of mineralization of the elastic membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00960491
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  • 8
    Electronic Resource
    Electronic Resource
    Calcinose und Spaltensystem der inneren elastischen Membran der geschlängelten Milzarterien (1968)
    Springer
    Virchows Archiv 345 (1968), S. 292-298 
    Details
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei der makroskopischen Darstellung von Kalkablagerungen treten die calcifizierten Anteile der inneren elastischen Membran auch an den Milzarterien in Form von gepaarten schwarzen Kalkbändern oder ihren Fragmenten zutage. Diese stellen mineralisierte Ränder von Membranspalten dar und lassen daher die Form und Ausdehnung der Membranlücken an der Innenwand der Arterie makroskopisch erkennen. Die äußeren, sich ausbuchtenden Bögen der geschlängelten Milzarterien zeigen an ihrer inneren elastischen Membran ein stark ausgebildetes Spaltensystem und erweisen sich zugleich als ein bevorzugter Sitz der Membrancalcinose. Die stärkere Entwicklung des Spaltensystems der primären inneren elastischen Membran an den äußeren Bögen der Krümmer stellt offenbar die Folge einer hier stattfindenden Wanddehnung dar, die auch an der Verdünnung der Wand und an dem Auseinanderweichen der adventitiellen elastischen Geflechte erkennbar wird.
    Notes: Summary Calcific deposits have been demonstrated grossly in the internal elastic membrane of splenic arteries. They are seen on the margins of membrane gaps as pairs of continuous or interrupted black bands (“calcific bands”). When the calcification is pronounced, nearly the whole system of ramifying and communicating membrane gaps is discerned grossly on the inner surface of the arteries. On the inside of the convex segments of the tortuous splenic arteries the membrane gaps are more numerous and wider then on the inside of the concave segments. Consequently, the calcific deposits are commoner on the convex segments. The development of gaps in the internal elastic membrane on the convex segments is probably the result of distension by the greater hydraulic pressure on these parts of the tortuous artery. This also leads to thinning of the media and interruption of the elastic networks in the adventitia in these parts of the artery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542685
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  • 9
    Electronic Resource
    Electronic Resource
    Der Morbus Fabry als Beispiel einer erblichen Lipoidspeicherkrankheit (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 72-76 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary New biochemical and pathological findings lead to the conclusion that Fabry's disease is a primary systematic disorder of the whole smooth musculature, of the heart-muscle and of the autonomic nervecells. The sometimes most striking storage of lipid in other cellgroups, e.g. in the kidney and the reticuloendothelial system must be regarded as secondary, the ceramide there being taken out of the urine or out of the blood. The primary involvement of certain cells can be explained by the supposition that trihexoseceramide, the substratum of the defect enzyme plays an important part in the metabolism of these cells. It seems to be possible to explain the other lipidoses in a similar way. — The systematic affection of the smooth musculature, the heart-muscle and the autonomic nervesystem as well as the secondary storage, especially in the lower nephrons of the kidneys are responsible for the multiple symptoms of Fabry's disease, which can thus be considered as the result of a single basic disorder.
    Notes: Zusammenfassung Neuere biochemische und pathologischanatomische Befunde sprechen dafür, daß es sich beim Morbus Fabry um eine primäre systematische Erkrankung der gesamten glatten Muskulatur, des Herzmuskels und der vegetativen Ganglienzellen handelt. Demgegenüber sind andere, unter Umständen sehr auffallende Lipoidablagerungen, z. B. in Niere und RES als sekundär aufzufassen und durch Aufnahme des Ceramids aus dem Harn bzw. dem Blut zu erklären. Der primäre Befall bestimmter Zellsysteme wird darauf zurückgeführt, daß in ihnen das Substrat des defekten Enzyms, das Trihexose-Ceramid als Metabolit eine besondere Rolle spielt. Derartige Überlegungen können mutatis mutandis auch für die übrigen Lipidosen angewandt werden. — Der regelhafte Befall von glatter Muskulatur, Herzmuskel und vegetativem Nervensystem, sowie von den sekundären Lipoidablagerungen vor allem die Speicherung in den Nierentubuli sind verantwortlich für das klinische Bild des M. Fabry und gestatten eine einheitliche Erklärung der so vielfältigen Symptomatologie.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01747471
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  • 10
    Electronic Resource
    Electronic Resource
    Enzymaktivitäten im menschlichen Serum nach posttraumatischer Milzexstirpation (1965)
    Springer
    Journal of molecular medicine 43 (1965), S. 49-51 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary This report deals with enzyme studies in posttraumatic spleenectomized patients. A significant rise in ALD-, MDH-, GOT- and GPT-activity, a significant lowering in G-6-PDH activity and no significant increase in LDH- and SDH-activity was noted following spleenectomy. The possibility that a cell system of the spleen was involved in the breakdown of the enzymes is discussed.
    Notes: Zusammenfassung Es wird über Enzymstudien an Patienten berichtet, bei denen als Folge eines Unfalls die Milz entfernt wurde. Nach Verlust dieses Organs wurde eine signifikante Erhöhung der Aktivität der ALD, MDH, GOT und GPT festgestellt. Nicht signifikant erhöht waren LDH- und SDH-Aktivität, während die G-6-PDH-Aktivität signifikant erniedrigt gefunden wurde. Die Möglichkeit, daß ein in der Milz enthaltenes Zellsystem am Enzymabbau beteiligt ist, wird diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485590
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