ISSN:
1573-4943
Keywords:
acetylcholine receptor
;
α-bungarotoxin
;
cobratoxin
;
α-neurotoxin
;
synthetic peptides
;
toxin-binding regions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract A set of 18 synthetic uniform overlapping peptides spanning the entire extracellular part (residues 1–210) of the α-subunit of human acetylcholine receptor were studied for their binding activity of125I-labeled α-bungarotoxin and cobratoxin. A major toxin-binding region was found to reside within peptide α122–138. In addition, low-binding activities were obtained with peptides α34–49 and α194–210. It is concluded that the region within residues α122–138 constitutes a universal major toxin-binding region for acetylcholine receptor of various species.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01025247
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