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  • 1985-1989  (2)
  • 1965-1969
  • N-Butyl-N-(4-hydroxybutyl)nitrosamine  (1)
  • caffeic acid ester  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 230-232 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Honebee hive ; propolis ; caffeic acid ester ; cytoxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. Many important pharmaceutical properties have been ascribed to propolis, including anti-inflammatory, antiviral, immunostimulatory and carcinostatic activities. Propolis extracts have provided an active component identified as caffeic acid phenethyl ester (CAPE), which was readily prepared in one step. Differential cytotoxicity has been observed in normal rat/human versus transformed rat/human melanoma and breast carcinoma cell lines in the presence of CAPE.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01941717
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Promoting effect of sodium chloride in 2-stage urinary bladder carcinogenesis in rats initiated by N-Butyl-N-(4-hydroxybutyl)-nitrosamine (1986)
    Springer
    Urological research 14 (1986), S. 201-206 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Rat bladder carcinogenesis ; Initiation and promotion ; N-Butyl-N-(4-hydroxybutyl)nitrosamine ; Urinary composition ; Sodium chloride
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The promoting effect of sodium chloride (NaCl) in 2-stage urinary bladder carcinogenesis in F344 rats initiated by 2 doses of N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) was investigated. The incidences of PN hyperplasia were significantly higher in rats initiated with 0.01 or 0.05% BBN when they were given diet containing 10% NaCl for 32 weeks than when they were given control diet. The incidence of papilloma in rats given 0.05% BBN followed by diet containing 10% or 5% NaCl tended to be higher than that in control rats. The urine of rats given diet containing NaCl was larger in volume and had lower osmolality than that of controls. The total urinary sodium and chloride contents were also increased, whereas those of potassium and phosphorus were decreased. No calculus formation or crystalluria was observed. These data suggest that excess intake of sodium as NaCl has a weak promoting effect in 2-stage urinary bladder carcinogenesis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00441114
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