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  • 1
    Electronic Resource
    Electronic Resource
    Brain monoamines after portacaval anastomosis (1986)
    Springer
    Metabolic brain disease 1 (1986), S. 45-52 
    Details
    ISSN: 1573-7365
    Keywords: hepatic encephalopathy ; high-performance liquid chromatography ; liver disease ; monoamine neurotransmitters ; portacaval shunting ; rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Norepinephrine, dopamine, and serotonin, as well as the serotonin metabolite, 5-hydroxy-indoleacetic acid, were measured in whole-brain extracts from rats with a portacaval shunt or sham operation. Norepinephrine, serotonin, and 5-hydroxyindoleacetic acid were significantly higher after shunting. There was no difference in dopamine. The results support the idea that brain indole metabolism is increased during chronic hepatic encephalopathy. However, they provide evidence against suggestions that hepatic encephalopathy in general is accompanied by a shortage in the whole-brain content of the catecholamines norepinephrine and dopamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00998476
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Regional blood-brain barrier transport of glucose after portacaval anastomosis (1986)
    Springer
    Metabolic brain disease 1 (1986), S. 119-128 
    Details
    ISSN: 1573-7365
    Keywords: glucose transport ; blood-brain barrier ; regional glucose utilization ; portacaval anastomosis ; hepatic encephalopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The regional influx of glucose across the blood-brain barrier was measured in rats 5 to 6 weeks after a portacaval anastomosis or sham operation. D-[14C]Glucose was infused intravenously for 15sec while arterial blood was sampled continuously for measurement of plasma radioactivity and glucose concentration. Brain tissue radioactivity was measured by quantitative autoradiography. Glucose influx and plasma clearance (permeability times surface area;PS) were calculated from the net disintegrations per minute per gram in brain, the plasma radioactivity integral, and the plasma glucose concentration. In shunted rats influx was decreased by about 22% (in the brain as a whole) compared to that in controls. This decrease was almost entirely due to the decrease in plasma glucose concentrations (27%). ThePS, normalized to take plasma concentrations into account, showed a slight decrease in most of the brain except the telencephalon. For the brain as a whole this decrease amounted to 11%. The regionalPS and glucose utilization are known to be coupled and the relationship between these was the same in sham-operated and shunted rats. The decrease inPS observed in shunted rats was commensurate with their lower rates of glucose use; thus, the transport process of glucose from plasma to brain appeared to be unaffected by portacaval shunting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00999382
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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