ISSN:
1432-1912
Keywords:
Nerve growth factor (NGF)
;
Rat basal forebrain
;
Cholinergic neurons
;
Monoaminergic neurons
;
Denervation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have investigated whether degeneration of basal forebrain cholinergic neurons is a potential trigger for increased NGF production in the adult rat brain. Electrolytic lesions of cholinergic neurons in the septum-diagonal band and in the nucleus basalis of Meynert induced a transient increase in NGF in the ventral hippocampus (+70%) and cerebral cortex (+125%), respectively. In contrast, selective aminergic denervation of the forebrain by electrolytic lesion of the medial forebrain bundle, did not increase NGF levels in hippocampus and cerebral cortex. Thus, a cholinergic mechanism appears to regulate NGF production in adult rat basal forebrain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00569368
Permalink
