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  • 1
    Digitale Medien
    Digitale Medien
    Structural selectivity of topological indexes in alkane series (1985)
    s.l. : American Chemical Society
    Journal of chemical information and modeling 25 (1985), S. 23-27 
    Details
    ISSN: 1520-5142
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ci00045a006
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  • 2
    Digitale Medien
    Digitale Medien
    Cooperativity of tetrodotoxin action in the frog node of Ranvier (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 237-243 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Node of Ranvier ; Na channels ; Tetrodotoxin ; Cooperativity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract 1. The steady state effects and rates of action of tetrodotoxin (TTX) on sodium current were studied in the voltage clamped frog node of Ranvier. 2. Inactivation of the sodium current was separated into fast and slow phases. Both phases were assumed to correspond to two different currents (fast and slow) flowing through fast and slow channels (Benoit et al. 1985). 3. The dose-response curve of the steady state effect of tetrodotoxin on the fast current was sigmoid. An analysis of this effect in double logarithmic coordinates gave a Hill coefficient of 1.74. 4. The rates of tetrodotoxin action on the fast current were determined by the reversible reduction of the peak current recorded at a potential (+20 mV) at which the slow current was relatively small. 5. After an initial delay, the onset of TTX effect followed an exponential function of time whose constant decreased with increasing tetrodotoxin concentrations. Expressed as the time corresponding to a reduction of 2% of the current, the delay (δt2%) increased from about 100 ms with 300 nM-TTX to about 30 s with 1 nM-TTX. 6. When tetrodotoxin was removed, the offset developed quasi-instantaneously and followed an exponential function of time whose constant was independent of the toxin concentration. 7. Both steady state and rates of tetrodotoxin effects could be fitted well if one assumed that the block of one fast channel occurred after binding of two TTX molecules to two cooperative sites.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00582567
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  • 3
    Digitale Medien
    Digitale Medien
    Chemical ideograms and molecular computer graphics (1985)
    Springer
    The visual computer 1 (1985), S. 49-63 
    Details
    ISSN: 1432-2315
    Schlagwort(e): Molecular modelling ; Computer-assisted drug design (CADD) ; Graphics language ; Molecular computer graphics (MCG) ; Chemical information systems
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract Molecular computer graphics (MCG) has become the indispensable complement of experimental chemical and biological tools and, in a way, will shape the evolution of these fields. This accelerated and popularized evolution takes root in the visual, even scenic, grasping of fundamental chemical concepts, perceived as veritable ideograms, which condense a vast amount of information with a few two- or threedimensional graphic symbols. With MCG one can carry out real computerized syntheses of chemical images. MCG is also an ideal tool through which to visualize the changes of a system as a function of time. This review article describes the potentials and advantages of structural MCG for visualizing the basic steps of important modelization concepts, particularly for handling on-line structures in information networks and in computer-assisted drug design (CADD) applications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01901269
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  • 4
    Digitale Medien
    Digitale Medien
    Grid stage modelling functions and molecular vector graphics (1986)
    Springer
    The visual computer 2 (1986), S. 367-378 
    Details
    ISSN: 1432-2315
    Schlagwort(e): Molecular polymodelling ; POLYMOD ; 3D Grid stage ; COOBOX ; Geometric and Boolean operations ; Composite images
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract A polymodelling system (POLYMOD) is presented for varied 2D or 3D displays of chemical shapes, whether structural (molecular volumes distances, surfaces...) or electronic (molecular electrostatic potential, electron densities ...). The POLYMOD system manages reversible correspondences between calculation and representation spaces by immersing the molecules studied in a unique represetation space structured by a 3D grid box. This box, called COOBOX, defined by its point internal coordinates, is used to transform other coordinates into its own. Direct multi-slice images along thex, y, z axis provide access to a variety of derived operations around a molecular shape or set of shapes disposed in various manners. Interactive sub systems ensure Boolean operations and compare property shapes through the 3D grid. Clear separation of graphic routine and of downstream modelling programs leads to rapid and original generation of varied images (subimages, direct or composite images) which are then available for simulation strategies.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01952421
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  • 5
    Digitale Medien
    Digitale Medien
    Radiation necrosis of the brain: Time of onset and incidence related to total dose and fractionation of radiation (1985)
    Springer
    Neuroradiology 27 (1985), S. 44-47 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Radiation therapy ; radiation injuries ; radiation dose-interval of onset ; incidence ; brain tumor
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Clinical deterioration during or after brain irradiation may be due to progression of neoplasm or radiation induced necrosis of the neoplasm and/or of normal brain tissues, or a combination of all. Eight patients with histologically documented radiation induced lesions of the brain are included in this study. The radiation therapy included the fractional schedule, group A, who received 280 to 300 rads daily, to a total dose of 4500 to 5000 rads and weekly exposure did not exceed 900 rads. Group B patients were exposed to 850 rads, daily dose on day 1, 3, 21 and 23 to a total dose of 3400 rads. The incidence of radiation induced lesions of brain was 3.4% in patients group A and 8.7% in group B patients (without) statistical significance). The median time of onset of these lesions after completion of radiation therapy was significantly shorter in group B patients (8.5 months) as opposed to group A patients (21 months).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00342516
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  • 6
    facet.materialart.
    Unbekannt
    Esquisse d'un dictionnaire structural (1962)
    Paris : Periodicals Archive Online (PAO)
    Etudes de linguistique appliquée. 1 (1962) 43 
    Details
    ISSN: 0071-190X
    Thema: Allgemeine und vergleichende Sprach- und Literaturwissenschaft. Indogermanistik. Außereuropäische Sprachen und Literaturen
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:t611-1962-001-00-000002
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  • 7
    facet.materialart.
    Unbekannt
    Recherches sur l'intonation française (1963)
    Paris : Periodicals Archive Online (PAO)
    Etudes de linguistique appliquée. 2 (1963) 147 
    Details
    ISSN: 0071-190X
    Thema: Allgemeine und vergleichende Sprach- und Literaturwissenschaft. Indogermanistik. Außereuropäische Sprachen und Literaturen
    Notizen: ANALYSE LINGUISTIQUE ET LINGUISTIQUE APPLIQUÉE
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:t611-1963-002-00-000011
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  • 8
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and metabolism of hexamethylmelamine in mice after IP administration (1986)
    Springer
    Cancer chemotherapy and pharmacology 18 (1986), S. 226-230 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pharmacokinetics of hexamethylmelamine (HMM) and its first metabolite (hydroxymethylpentamethylmelamine HMPMM) following IP bolus dose of 200 mg/kg were studied in mice. The drug concentrations were determined by a sensitive reversed-phase HPLC assay. Thus, for the first time, HMM major hydroxylated and demethylated metabolite plasma levels canbedetermined at the same time. Pharmacokinetic data were analyzed by an original method using a nonlinear cost function minimized by a simplex algorithm. An important property of this computer program is that convergence is ensured in contrast to linear or nonlinear least-square regression analysis, which leads to lack of convergence or to false convergence. Both HMM and HMPMM data fit a one-compartment open model. The parameters obtained indicate that the parent drug would probably be rapidly and completely transformed by the human body into HMPMM.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00273391
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  • 9
    Digitale Medien
    Digitale Medien
    Structure de la tétra(p-n-octylphényl)-5,10,15,20 porphine de zinc(II) (1988)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 44 (1988), S. 429-432 
    Details
    ISSN: 1600-5759
    Quelle: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1107/S0108270187010849
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  • 10
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and metabolism of hexamethylmelamine in mice bearing renal cell tumors (1988)
    Springer
    Cancer chemotherapy and pharmacology 22 (1988), S. 282-288 
    Details
    ISSN: 1432-0843
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pharmacokinetics of hexamethylmelamine (HMM) and its main metabolites hydroxymethylpentamethylmelamine (HMPMM), pentamethylmelamine (PMM), and 2,2,4,6 tetramethylmelamine (2,2,4,6 TetrMM) were studied in renal cell (RC) tumor tissues and plasma of CDF1 mice that had received IP bolus injections of the maximally tolerated dose (200 mg/kg) of HMM. HMM, PMM, and 2,2,4,6 Tetr MM concentrations determined in RC tissues were much higher than the plasma values, as indicated by the pharmacokinetic parameters (Cmax and AUC). On the other hand, very low levels of HMPMM, generally considered to be a potentially active antitumor compound, were detected in the target tissues, whereas this hydroxylated metabolite was stable and easily determined in plasma. High HMM concentrations in RC tissues could correlate with the high sensitivity of the tumor to this drug. However, the behavior of HMPMM remains unclear; related hypotheses are presented in this paper.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00254232
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