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Possible site of bronchodilation due to inhaled procaterol aerosol in asthmatic patients (1988)

Taguchi, O. ; Hida, W. ; Nogami, H. ; [et al.]

Springer

European journal of clinical pharmacology 34 (1988), S. 433-437

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ISSN: 1432-1041

Keywords: procaterol ; airway responsiveness ; bronchodilator ; dynamic compliance ; Fourier analysis

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary We studied the effective site of an inhaled aerosol of procaterol, a β2-selective adrenergic bronchodilator, in 8 asthmatic patients whose basal lung functions are almost within the normal range in both slow vital capacity (VC) and forced expiratory volume in one second (FEV1.0), and are free from asthmatic attack. In patients who had received procaterol 30 min after inhalation of aerosol, there was no significant change in VC, although FEV1.0, maximal expiratory flow at 50% VC $$(\dot V_{50} )$$ , maximal expiratory flow at 25% VC $$(\dot V_{25} )$$ and maximal expiratory flow at 30% VC of partial maximal expiratory flow volume curve $$(\dot V_{30p} )$$ improved significantly. On the other hand, in those who had received placebo, none of the parameters changed. Furthermore, Rl decreased and C0.5 increased significantly during the first 5 min after inhalation of procaterol aerosol. After an interval of 5 min, Rl did not change any further, while C0.5 continued to improve until 30 min after inhalation of procaterol. These results suggest that procaterol may first dilate the large airway and then may gradually dilate the small airway in bronchial asthma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01046698

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Effect of organic solvents on the activity of glucoamylase (1986)

Nagamoto, H. ; Yasuda, T. ; Inoue, H.

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 28 (1986), S. 1172-1177

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ISSN: 0006-3592

Keywords: Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Hydrolyses of maltose, maltotriose, and soluble starch catalyzed by glucoamylase (Asp. Niger) were carried out in the aqueous solutions of methanol, ethanol, ethylene glycol, and 1,4-dioxane at 40°C and at the optimum pH in the respective solutions. By the kinetic analysis based on the subsite model, it was shown that the intrinsic rate constant, Kint, was electrostatically affected by the dielectric constant of the hydroorganic solutions. The affinity of the third subsite, A3, which affects the apparent rate constant, K0, was correlated with the ×Gtr's of maltose and amino acid side chains.

Additional Material: 5 Ill.