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  • 1985-1989  (2)
  • 1960-1964
  • Computer-assisted drug design (CADD)  (1)
  • Cooperativity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cooperativity of tetrodotoxin action in the frog node of Ranvier (1985)
    Springer
    Pflügers Archiv 405 (1985), S. 237-243 
    Details
    ISSN: 1432-2013
    Keywords: Node of Ranvier ; Na channels ; Tetrodotoxin ; Cooperativity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. The steady state effects and rates of action of tetrodotoxin (TTX) on sodium current were studied in the voltage clamped frog node of Ranvier. 2. Inactivation of the sodium current was separated into fast and slow phases. Both phases were assumed to correspond to two different currents (fast and slow) flowing through fast and slow channels (Benoit et al. 1985). 3. The dose-response curve of the steady state effect of tetrodotoxin on the fast current was sigmoid. An analysis of this effect in double logarithmic coordinates gave a Hill coefficient of 1.74. 4. The rates of tetrodotoxin action on the fast current were determined by the reversible reduction of the peak current recorded at a potential (+20 mV) at which the slow current was relatively small. 5. After an initial delay, the onset of TTX effect followed an exponential function of time whose constant decreased with increasing tetrodotoxin concentrations. Expressed as the time corresponding to a reduction of 2% of the current, the delay (δt2%) increased from about 100 ms with 300 nM-TTX to about 30 s with 1 nM-TTX. 6. When tetrodotoxin was removed, the offset developed quasi-instantaneously and followed an exponential function of time whose constant was independent of the toxin concentration. 7. Both steady state and rates of tetrodotoxin effects could be fitted well if one assumed that the block of one fast channel occurred after binding of two TTX molecules to two cooperative sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582567
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Chemical ideograms and molecular computer graphics (1985)
    Springer
    The visual computer 1 (1985), S. 49-63 
    Details
    ISSN: 1432-2315
    Keywords: Molecular modelling ; Computer-assisted drug design (CADD) ; Graphics language ; Molecular computer graphics (MCG) ; Chemical information systems
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract Molecular computer graphics (MCG) has become the indispensable complement of experimental chemical and biological tools and, in a way, will shape the evolution of these fields. This accelerated and popularized evolution takes root in the visual, even scenic, grasping of fundamental chemical concepts, perceived as veritable ideograms, which condense a vast amount of information with a few two- or threedimensional graphic symbols. With MCG one can carry out real computerized syntheses of chemical images. MCG is also an ideal tool through which to visualize the changes of a system as a function of time. This review article describes the potentials and advantages of structural MCG for visualizing the basic steps of important modelization concepts, particularly for handling on-line structures in information networks and in computer-assisted drug design (CADD) applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01901269
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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