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Lung function of workers exposed to antigens from a contaminated air-conditioning system (1985)

Pal, T. M. ; Kaufmann, H. F. ; Monchy, J. G. R. ; [et al.]

Springer

International archives of occupational and environmental health 55 (1985), S. 253-266

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ISSN: 1432-1246

Keywords: Humidifier fever ; Lung function ; Skin test ; Serology ; Smoking habits

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Following the manifestation of humidifier fever in a number of workers in a carpet yarn texturing plant, a comparative study was begun of a group of workers exposed to fungi from the air-conditioning system and a control group not so exposed. For both group of workers anamnestic data were collected, intracutaneous skin tests were performed, certain lung function parameters were determined, and the presence of antibodies to a number of antigens from the system was tested for. It was found that the group of exposed workers had a significantly higher rate of positive intracutaneous skin test than non-exposed workers. Additionally, their serology was more often positive. Both positive skin test and positive serology were more frequent in non-smokers than in smokers. A positive immediate skin reaction among exposed workers was found to correlate with an FEF25–75 reduction during the working week. A positive delayed skin reaction among exposed workers correlated with a lower FVC prior to the start of the working week than recorded for non-exposed workers. A positive serology in exposed workers did not correlate with a difference in lung function compared with non-exposed workers, nor was there a correlation with a change in lung function in the course of the working week. When humidifier fever is diagnosed, steps should be taken to reduce exposure. It would also appear desirable to keep exposed workers under medical observation and to monitor the subsequent development of their lung function.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00383758

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Die Cardenolide von Gongronema gazense (S. MOORE) BULLOCK. Zweite Mitteilung. Glykoside und Aglykone, 247. Mitteilung (1963)

Lewbart, M. L. ; Wehrli, W. ; Kaufmann, H. ; [et al.]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 46 (1963), S. 517-529

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ISSN: 0018-019X

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Die Teilsynthese von 3-epi-Sarmentogenin aus Sarmentogenin wird beschrieben. Die Struktur der Glykoside C, E, G, L, M und R aus Gongronema gazense wird weitgehend abgeklärt. Sie besitzen folgende Zusammensetzung: C = Sarmentogenin-triscymarosid (VII), E = Sarmentogenin-bis-cymarosid (VIII), G = Sarmentogenin-biscymarosido-digitoxosid (X), L = Periplogenin-cymarosido-digitoxosid (XIII), M = Sarmentogenin-cymarosido-digitoxosid (XI) und R = Sarmentogenin-oleandrosidobis-digitoxosid (XVI). Durch partielle Hydrolyse von C liess sich E sowie das noch unbekannte Sarmentogenin-cymarosid (IX) gewinnen, aus G entstand analog M und das ebenfalls neue Sarmentogenin-digitoxosid (XII), aus L das bekannte Periplogenindigitoxosid (XIV) und aus R neben XI1 das nur papierchromatographisch nachgewiesene Sarmentogenin-bis-digitoxosid XVII. - In diesen Glykosiden sind die Zucker nur papierchromatographisch und durch Dünnschichtchromatographie identifiziert worden. Es ist demnach nicht bewiesen, ob D- oder I.-Formen vorliegen. Die Reihenfolge der Zucker ist gut gesichert, die Art der Verknüpfung derselben (α- oder β-glykosidisch, pyranosidisch oder furanosidisch) aber nur fur die Monoglykoside.

Additional Material: 5 Ill.