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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 81 (1959), S. 2214-2219 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Clinicopathological and immunohistological features of three cases of large cell lymphoma of bone are reported. On histological grounds, all the cases were diagnosed as histiocytic lymphomas (Rappaport) or primary centroblastic lymphomas, polymorphic subtype (Kiel). On immunophenotyping, malignant cells strongly reacted with the anti-ieucocyte antibodies PD7/26 and ROS-220C, thereby indicating their lymphomatous nature, and expressed the B-cell antigens CD19 and CD22. Further studies are warranted to determine whether the B-cell phenotype observed in our cases is typical of the majority of primary large cell lymphomas of bone. Immunohistological analysis with monoclonal antibodies is expected to be of great value not only in defining the immunological phenotype of this rare pathological entity, but also in differentiating it from other neoplasms that involve the skeleton, either primarily or secondarily.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The phenotype of 36 cases of hairy cell leukaemia has been investigated using a panel of monoclonal antibodies reactive with normal human lymphoid cells and with hairy cells. Staining was performed on frozen sections and/or cell smears by the recently developed APAAP immuno-alkaline phosphatase procedure. In about 90% of cases, neoplastic cells reacted strongly with antibodies against HLA-DR, leucocyte common antigen, B-cells (antibodies B1 and To15), hairy-associated antigens (antibodies KB-90, S-HCL3, HC2) and activated T-lymphocytes (antibodies anti-Tac and Tü69). The phenotype of 10% of cases was clearly different in that the neoplastic cells were negative or only weakly positive for one or more of the antigens recognized by HC2, anti-Tac and Tü69. Antibody HC1 reacted with tumour cells of only 50% of the hairy cell leukaemia cases investigated. Monoclonal antibody Ki-67 (which selectively detects proliferating cells) stained only a low percentage of cells in all but three of the cases studied. The neoplastic cells in all cases were unreactive with monoclonal antibodies
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 44 (1988), S. 882-885 
    ISSN: 1420-9071
    Keywords: Flavonoids ; DNA polymerase ; RNA polymerase ; inhibitory effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Flavonoids, (−)-epigallocatechin (1), myricetin (2) and quercetin (3), were investigated for inhibitory effects onE. coli DNA polymerase I and T7 bacteriophage RNA polymerase. In both DNA and RNA synthesis,1 and3 inhibited enzyme reactions by non-competitive and mixed type inhibition respecitively, with regard to template DNAs. Myricetin (2) inhibited DNA and RNA polymerase reactions by mixed type and competitive type inhibition, respectively, with template DNAs. It was suggested that2 interacts with covalently closed/circular DNA.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Insectes sociaux 34 (1987), S. 136-141 
    ISSN: 1420-9098
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Resume Afin de déterminer le rôle de l'expérience sociale précoce sur l'ontogenèse de la reconnaissance des cocons par une espèce esclave de fourmi, des expériences de laboratoire ont été réalisées surFormica cunicularia, une espèce communément esclave deFormica sanguinea. Dans un test de choix, des ouvrières adultes deF. cunicularia provenant d'une colonie pure soignèrent uniquement des cocons homospécifiques, tandis qu'elles détruisirent les cocons hétérospécifiques, non familiers (F. sanguinea etF. lugubris). Après quoi, 3 groupes de colonies artificielles ont été constitués avec de jeunes ouvrières deF. cunicularia de même âge, retirées expérimentalement de leurs cocons. Après une période d'entraînement de quinze jours avec des cocons homospécifiques (groupe C), des cocons deF. sanguinea (groupe T), on en l'absence de tout cocon (groupe I), ces ouvrières furent soumises à un test de choix entre des cocons deF. cunicularia et deF. sanguinea. Le choix des ouvrières des groupes C et T fut toujours en faveur des cocons auxquels elles avaient été familiarisées au cours de la période d'entraînement. En outre, la privation des cocons rompit la discrimination des cocons et l'aptitude aux soins des fourmis du groupe I. Sur la base de ces données et de celles que nous avons obtenues récemment sur la reconnaissance des partenaires du nid chez la même espèce, nous pouvons soutenir que l'expérience sociale suivant immédiatement l'éclosion chez l'ouvrière deF. cunicularia peut expliquer son esclavage dans la nature et, par conséquent, l'altruisme interspécifique de cet hôte à l'égard de son parasite.
    Notes: Summary In order to determine the role of early social experience on the ontogeny of cocoon recognition by a slave-ant species, laboratory experiments were carried out inFormica cunicularia, a common slave ofFormica sanguinea. In a choice-test, adultF. cunicularia workers coming from a pure colony tended only the homospecific cocoons, whereas destroyed the heterospecific unfamiliar ones (F. sanguinea andF. lugubris). Subsequently, 3 groups of artificial colonies were set up with callowF. cunicularia workers of the same age experimentally removed from their cocoons. After a 15-day training period with homospecific cocoons (group C),F. sanguinea cocoons (group T), or in absence of any cocoons (group I), these workers were given a choice-test betweenF. cunicularia andF. sanguinea cocoons. The choice of the workers belonging to groups C and T was always directed towards the cocoons with which workers had become familiar during the training period. Moreover, early deprivation of cocoons disrupted the cocoon discrimination and care ability of ants belonging to group I. On the basis of these data and those recently obtained by us on nestmate recognition in the same species, we can assume that social experience immediately following eclosion ofF. cunicularia workers can fully explain their enslavement in nature and, therefore, the interspecific altruism of this host species towards the parasite.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 58 (1985), S. 440-442 
    ISSN: 1432-1106
    Keywords: Monkey ; Second somatosensory (SII) cortex ; Intracortical microstimulation (ICMS) ; Low threshold movements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Threshold for evoking movements by microstimulation of the second somatosensory area of the cynomolgus monkey's cortex to intracortical microstimulation was examined. Motor effects were obtained contralateral to the side of stimulation, in a region histologically verified to be in grey matter deep in the sylvian cortex, and which corresponds to the second somatosensory cortex. The thresholds were low but higher than for movements evoked by stimulation of the motor cortex. The results are explained in terms of increased specialization of the motor cortex for movements in the monkey compared with the cat.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-6903
    Keywords: Ketamine ; cholecystokinin ; somatostatin ; substance P
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intraperitoneal injection of ketamine (100 mg/kg body weight) significantly reduces the levels of cholecystokinin (CCK) somatostatin (SRIF), and substance P (SP)-like immunoreactivity in various regions of rat brain. No significant change in thyrotropin releasing hormone (TRH)-like immunoreactivity was observed. Neuropeptide systems may be involved in the neuropharmacologic effects of ketamine.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-6903
    Keywords: Parallel assay ; CAT ; muscarinic cholinergic receptor ; aged-rat brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have devised a method for the parallel determination of choline acetyltransferase (CAT) and muscarinic cholinergic receptor (mCh-R) in the same brain tissue. The method for CAT activity determination is more rapid, simplified, stable, and economical than the usual Fonnum's method. With our method, age-associated changes in CAT activity and mCh-R levels were examined. Although CAT activity hardly changed with age except in a few areas, mCh-R binding of aged-rats was markedly reduced in all areas. These results suggest that the change in mCh-R represents an age-associated biochemical change in the brain and that determination of CAT activity is not sufficient for the study of age-associated changes in the brain cholinergic system.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Neurochemical research 11 (1986), S. 37-45 
    ISSN: 1573-6903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Emotional stress markedly inhibited E1 mouse convulsions. Norepinephrine and dopamine levels in E1 mouse brain were hardly affected by stress, though a marked decrease in norepinephrine and dopamine levels was observed in the ddY mouse brain. The serotonin levels decreased in the E1 mouse brain in the same degree as in the ddY mouse brain. These findings suggest that the serotonergic system is involved in the inhibition of E1 mouse convulsions, through an enhanced serotonin release in the brain brought on by the emotional stress. Noradrenergic and dopaminergic systems may also be involved.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Biotechnology letters 11 (1989), S. 183-188 
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary Released free cells of immobilized growing acetic acid bacteria during 460 days of long run in a bioreactor were increased at a high dilution rate. This was interpreted by the facts that newly released cells from the carrier showed a synchronized growth and had extremely high growth rates and a respiratory activity. The suitable leakage is effective for high productivity of the immobilized growing cell culture.
    Type of Medium: Electronic Resource
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