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  • 1
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    The Pope and European Dictatorship (1940)
    London : Periodicals Archive Online (PAO)
    The Contemporary Review. 157 (1940:Jan./June) 61 
    Details
    ISSN: 0010-7565
    Topics: General, Interdisciplinary
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0274-1940-157-00-000008
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  • 2
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    The Independence of Switzerland (1941)
    London : Periodicals Archive Online (PAO)
    The Contemporary Review. 159 (1941:Jan./June) 658 
    Details
    ISSN: 0010-7565
    Topics: General, Interdisciplinary
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0274-1941-159-00-000083
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  • 3
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    The Russian Front through German Eyes (1942)
    London : Periodicals Archive Online (PAO)
    The Contemporary Review. 162 (1942:July/Dec.) 341 
    Details
    ISSN: 0010-7565
    Topics: General, Interdisciplinary
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0274-1942-162-00-000073
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  • 4
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    The Decline of Hitler's Power (1944)
    London : Periodicals Archive Online (PAO)
    The Contemporary Review. 165 (1944:Jan./June) 335 
    Details
    ISSN: 0010-7565
    Topics: General, Interdisciplinary
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0274-1944-165-00-000068
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  • 5
    Electronic Resource
    Electronic Resource
    Binding of [3H]ouabain to endothelial cells derived from various vascular beds (1987)
    Springer
    Basic research in cardiology 82 (1987), S. 544-550 
    Details
    ISSN: 1435-1803
    Keywords: endothelial cells ; [3H]ouabain binding ; ouabain receptors ; Na+/K+-ATPase ; vascular beds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Binding experiments were performed with [3H]ouabain on plasma membranes derived from several types of isolated and cultivated endothelial cells. Identical saturation curves for [3H]ouabain binding to endothelial cells form pig aorta, caval vein, and pulmonary artery were obtained with a dissociation constant (KD) of 3.29±0.31 nmol/l and a binding capacity (Bmax) of 5.22±0.12 pmol/mg protein. On guinea-pig coronary endothelial cells, saturation of [3H]ouabain revealed much lower affinity (KD 95±15 nmol/l, Bmax 2.08±0.09 pmol/mg protein). All Scatchard plots were linear, indicating a homogeneous class of binding sites. In competition experiments, cardiac glycosides and their aglycons displaced the radioligand with a structure-activity relationship typical for interaction with Na+/K+-ATPase (proscillaridin A〉ouabain〉digoxin〉g-strophanthidin〉digoxigenin〉dihydrodigoxin); in particular, removal of the sugar moiety results in considerable reduction of affinity. Furthermore, K+ displayed a steep inhibition curve with a half-maximal inhibitory constant of 2 mmol/l. All these findings suggest the presence of endothelial ouabain receptors linked to Na+/K+-ATPase. However, direct measurement of this enzyme was not possible due to an extremely high Mg2+-ATPase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01907224
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  • 6
    Electronic Resource
    Electronic Resource
    Cardiac ventricular β2-adrenoceptors in guinea-pigs and rats are localized on the coronary endothelium (1986)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 334 (1986), S. 56-62 
    Details
    ISSN: 1432-1912
    Keywords: β-Adrenoceptor antagonists ; β-Adrenoceptor subtypes ; Cardiac sarcolemma ; Cardiomyocytes ; Coronary endothelial cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In mammalian heart tissue β2 are known to coexist with β1. In the present study, evidence that β2 in guinea-pig and rat ventricles are primarily localized on the coronary endothelium is provided by competition binding studies with the subtype-selective β-adrenoceptor antagonists ICI 89.406 (β1) and ICI 118.551 (β2) on four different plasma membrane preparations. (1) Following density gradient centrifugation of cardiac ventricular microsomes from rats or guinea-pigs, endothelial plasma membranes migrated at slightly higher density than the sarcolemmal membranes, as verified by endothelial (angiotensin converting enzyme) and sarcolemmal markers (adenylate cyclase, [3H] ouabain binding). At the activity peak of angiotensin converting enzyme, the relative amount of β2 in guinea-pigs and rats was 25% and 65%, respectively. (2) On sarcolemmal membranes corresponding to the activity peak of adenylate, cyclase, β-adrenoceptors consisted of the β1 exclusively (guinea-pig), or to at least 90% (rat). (3) Cultures of coronary endothelial cells derived from guinea-pigs revealed only β2. (4) Isolated guinea-pig cardiomyocytes contained only β1, a finding recently established in rat myocytes as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498740
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  • 7
    Electronic Resource
    Electronic Resource
    Simultaneous determination of six tumor markers in patients with prostatic carcinoma and bladder tumors (1985)
    Springer
    Urological research 13 (1985), S. 133-136 
    Details
    ISSN: 1434-0879
    Keywords: Tumor marker ; Prostatic carcinoma ; Bladder carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum levels of fucosyltransferase (FT), phosphohexoseisomerase (PHI), tissue polypeptide antigen (TPA), Tennessee antigen (TAG), carcinoembryonic antigen (CEA) and prostatic acid phosphate (PAP) were determined in 75 healthy individuals and in 86 patients with prostatic carcinoma and 38 patients with bladder tumors. The discrimination capacities of the different markers were compared by using inverse distribution plots. At a rate of 5% false positive values the sensitivities for bladder tumors were: FT 30%, TPA 24%, CEA 16%, TAG 15%. The sensitivities for prostatic carcinoma were: PAP 63%, PHI 36%, TPA 18%, CEA 14%, TAG 14%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256074
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  • 8
    Electronic Resource
    Electronic Resource
    Glomeruli and microvessels of the rabbit kidney contain both A1- and A2-adenosine receptors (1987)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 335 (1987), S. 438-444 
    Details
    ISSN: 1432-1912
    Keywords: A1- and A2-adenosine receptors ; Renal cortex ; Glomeruli ; Microvessels ; Adenylate cyclase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rabbit renal cortices were fractionated by collagenase dispersion and glomeruli, microvessels and tubuli purified on a discontinuous sucrose gradient. Binding experiments with (−)[125I]N6-(4-hydroxyphenylisopropyl)-adenosine ([125I]HPIA) provided evidence for the presence of A1-adenosine receptors in the glomerular and microvascular fraction. With glomeruli, saturation isotherms for specific [125I]HPIA binding were mono-phasic with a K D of 1.3 nmol/l and a B maxof 7.7 fmol/mg protein. In kinetic experiments, an association rate constant of 4.9 × 105 (mol/ 1)−1 s−1 and a dissociation rate constant of 4.3 × 10−4 s−1 were obtained, yielding a K D of 0.9 nmol/l. Adenosine analogs displaced [125I]HPIA binding with a rank order of potency typical of A1-adenosine receptors; furthermore, binding was inhibited by methylxanthines and modulated by GTP. Saturation experiments with the microvessels revealed a K D of 1.9 nmol/l and a B max of 13.4 fmol/mg protein. However, no inhibition of glomerular and microvascular adenylate cyclase activity could be demonstrated, but instead both 5′-N-ethylcarboxamido-adenosine (NECA) and N6-(R-phenylisopropyl)-adenosine (R-PIA) stimulated enzyme activity, with EC50 values of 0.14 μmol/l and 1.5 μmol/l, respectively. The concentration-response curve for NECA was shifted to the right (factor 9) by 10 μmol/l 8-phenyltheophylline. On the other hand, computer simulation of biphasic curves (adenylate cyclase inhibition in the presence of activation via a stimulatory receptor) indicates that the failure to observe an A1-adenosine receptor-mediated inhibition of adenylate cyclase activity in the presence of stimulatory adenosine receptors may be attributable to methodological constraints. The results demonstrate that both A1- and A2-adenosine receptors are present in rabbit glomeruli and microvessels. It is suggested that both receptors are involved in the control of renin secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00165560
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  • 9
    Electronic Resource
    Electronic Resource
    Cooperative stimulation by sulfite and crocidolite asbestos fibres of enzyme catalyzed production of reactive oxygen species (1988)
    Springer
    Archives of toxicology 62 (1988), S. 424-427 
    Details
    ISSN: 1432-0738
    Keywords: Asbestos ; Xanthine oxidase ; NADH-diaphorase ; Lung diseases ; Oxygen activation ; OH-radical
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methylthioketobutyric acid has been used as an indicator for the production of reactive oxygen species during incubation with xanthine oxidase or NADH diaphorase in the presence of an autooxidizable quinone. The production of OH-radical-type oxidants is enhanced in the presence of crocidolite but not by the asbestos types chrysotile or amosite. This activity of crocidolite in the diaphorase system is further stimulated by bisulfite. Crocidolite-dependent ethylene formation from methylthioketobutyric acid is inhibited by both superoxide dismutase and catalase. In the presence of both crocidolite and bisulfite, however, the inhibition by superoxide dismutase is preserved, but the inhibition by catalase is lost. Since in some respect the NADH-diaphorase quinone system may reflect the situation in the activated macrophage, crocidolite activation may represent a biochemical model system describing potential asbestos toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288344
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  • 10
    Electronic Resource
    Electronic Resource
    Reply to the discussion of A. J. Bernard and E. Soler on the publication by P. Möller et al. (1985)
    Springer
    Mineralium deposita 20 (1985), S. 67-68 
    Details
    ISSN: 1432-1866
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00204264
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