ISSN:
1573-6903
Keywords:
Prazosin
;
[3H]Noradrenaline release
;
presynaptic alpha2-adrenoceptors
;
dissociation of alpha2-adrenoceptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Neurochemical and pharmacological evidence has been obtained that noradrenergic varicosities (in mouse and rat vas deferens) and cholinergic varicosities (in the Auerbach's plexus) contain heterogenous alpha2-adrenoceptors through which the release of [3H]noradrenaline and [3H]acetylcholine can be modulated. The quantitative data also support the hypothesis that different noradrenaline and xylazine sensitive alpha2-adrenoceptors are present prejunctionally in the vas deferens and Auerbach's plexus preparations. Prazosin, although it has a presynaptic inhibitory effect on alpha2-adrenoceptors of noradrenergic axon terminals, has no effect on cholinergic axon terminals. These data suggest that there are two different types of alpha2-adrenoceptors at the presynaptic axon terminals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00979530
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