ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis of (+)-Aspicilin Using Building Blocks from Renewable ResourcesThe 18-membered lichen macrolide (+)-aspicilin (1) is easily built up from compounds 14, 16, 3, and 24 following the C3 + C7 + C6 + C2 = C18 pattern (see Schemes). The synthesis requires 15 steps and gives 1 in 13% overall yield from D-mannose (2). The latter compound provides the stereogenic centers C(4), C(5), and C(6). The stereogenic center C(17) is supplied by building block 14 (from (-)-(S)-ethyl lactate).
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19890720813
Permalink