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  • 1985-1989  (3)
  • 1920-1924
  • Michaelis-Menten equation  (2)
  • 2-D echo  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Hydrodynamics in the heart modulates work (1988)
    Springer
    Heart and vessels 4 (1988), S. 128-135 
    Details
    ISSN: 1615-2573
    Keywords: H-1 NMR ; 2-D echo ; Isovolumic heart ; Hydrodynamics ; Intracellular water ; Intracellular calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The hydrostatic pressure (perfusion pressure) of the isovolumic isolated perfused rat heart regulated the hydrodynamics (water movement) of the myocardium. An abrupt (10 s) decrease in hydrostatic pressure caused an immediate decrease in oxygen consumption, left ventricular developed pressure, and wall thickness. Wall thickness was determined by two-dimensional echocardiography. When the perfusion pressure was again returned to the control values (140 cm H2O) oxygen consumption, developed pressure, and wall thickness returned to control values within 10–30 s. An abrupt decrease in perfusion pressure also caused an immediate decrease in both extracellular and intracellular water in the heart as determined by H-1 NMR (nuclear magnetic resonance) with the shift reagent Dy(TTHA)3− (Dysprosium triethylene tetramine-hexaacetate). Similar findings were obtained using K(CoEDTA) (potassium cobalt ethylenediaminetetraacetate) utilized as an extracellular marker. With a decrease in intracellular water in the heart, there was a concurrent decrease in intracellular calcium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02058424
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Kinetics of serotonin uptake in the intact lung (1987)
    Springer
    Annals of biomedical engineering 15 (1987), S. 217-227 
    Details
    ISSN: 1573-9686
    Keywords: Pulmonary endothelium ; Carrier-mediated transport ; Michaelis-Menten equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The pulmonary endothelium is capable of removing and metabolizing serotonin (5HT) carried in the venous blood. Thus the lungs can influence the arterial concentrations of 5HT. In addition, there is evidence that changes in the lung uptake of 5HT might portend more serious endothelial damage wherein the barrier function of the endothelium is compromised. This has been a stimulus for finding methods for evaluating these endothelial functions. These methods must be able to distinguish changes in whole organ function which result from changes in perfusion (e.g., cardiac output, redistribution of flow, etc.) from those resulting from changes in the function of the endothelial cells. When a bolus containing radio-labeled 5HT and an unmetabolizable indicator which is confined to the vascular space is injected into the pulmonary artery, the pulmonary venous or systemic arterial concentration curves contain information about both the convective transport and endothelial cell process involved. Some of this information can be interpreted quantitatively using a simple mathematical model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02364056
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Kinetics of uptake and metabolism by endothelial cell from indicator dilution data (1987)
    Springer
    Annals of biomedical engineering 15 (1987), S. 201-215 
    Details
    ISSN: 1573-9686
    Keywords: Saturable transport ; Endothelial metabolism ; Michaelis-Menten equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Certain substrates are rapidly taken up and/or metabolized by pulmonary endothelial cells in a saturable process. When such a substrate and a reference indicator are included in a bolus which is injected into the blood flowing into the lung, the extraction ratio, E(t), curves measured in the pulmonary venous outflow are asymmetric with respect to the reference indicator curve. If a sufficient quantity of substrate is included in the bolus, the extraction curves are concave upward. The shapes of the E(t) curves contain information regarding the chemical-physical processes which govern the fate of the substrate during its single passage through the lung. To interpret the shapes, computer simulations are used to illustrate separately the effects of the uptake of substrate into the cell, the returning flux of the substrate from the cell, the saturation phenomena of the extraction process, and the perfusion heterogeneity of the capillaries. Lastly, a simple analytical method for estimating the organ kinetic parameters of the extraction process is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02364055
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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