ISSN:
1432-2072
Keywords:
Ethylketazocine
;
Morphine
;
Naloxone
;
Competitive antagonism
;
Schedule-controlled behavior
;
Pigeons
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The behavioral effects of morphine and ethylketazocine were compared in pigeons responding under multiple fixed-interval, fixed-ratio schedules of food presentation. Both morphine and ethylketazocine produced dose-related decreases in rates of responding maintained under either schedule. Maximal effects of morphine were observed about 15–45 min after injection and typically lasted the entire session (about 60 min). Effects of ethylketazocine had a faster onset (maximal effects were observed within 15 min after injection), and shorter duration (effects diminished within the session). Ethylketazocine and morphine had similar potencies. Dose-effect curves for both drugs were shifted to a similar degree by naloxone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00176486
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