Library

X
Language
Preferred search index
Number of Hits per Page
Default Sort Criterion
Default Sort Ordering
Size of Search History
Default Email Address
Default Export Format
Default Export Encoding
Facet list arrangement
Maximum number of values per filter
Auto Completion
Feed Format
Maximum Number of Items per Feed
Permalink If you want to be able to use settings permanently, you must save your settings and then set a Bookmark to the permalink
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Kinetics of serotonin uptake in the intact lung (1987)
    Springer
    Annals of biomedical engineering 15 (1987), S. 217-227 
    Details
    ISSN: 1573-9686
    Keywords: Pulmonary endothelium ; Carrier-mediated transport ; Michaelis-Menten equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The pulmonary endothelium is capable of removing and metabolizing serotonin (5HT) carried in the venous blood. Thus the lungs can influence the arterial concentrations of 5HT. In addition, there is evidence that changes in the lung uptake of 5HT might portend more serious endothelial damage wherein the barrier function of the endothelium is compromised. This has been a stimulus for finding methods for evaluating these endothelial functions. These methods must be able to distinguish changes in whole organ function which result from changes in perfusion (e.g., cardiac output, redistribution of flow, etc.) from those resulting from changes in the function of the endothelial cells. When a bolus containing radio-labeled 5HT and an unmetabolizable indicator which is confined to the vascular space is injected into the pulmonary artery, the pulmonary venous or systemic arterial concentration curves contain information about both the convective transport and endothelial cell process involved. Some of this information can be interpreted quantitatively using a simple mathematical model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02364056
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Kinetics of uptake and metabolism by endothelial cell from indicator dilution data (1987)
    Springer
    Annals of biomedical engineering 15 (1987), S. 201-215 
    Details
    ISSN: 1573-9686
    Keywords: Saturable transport ; Endothelial metabolism ; Michaelis-Menten equation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Certain substrates are rapidly taken up and/or metabolized by pulmonary endothelial cells in a saturable process. When such a substrate and a reference indicator are included in a bolus which is injected into the blood flowing into the lung, the extraction ratio, E(t), curves measured in the pulmonary venous outflow are asymmetric with respect to the reference indicator curve. If a sufficient quantity of substrate is included in the bolus, the extraction curves are concave upward. The shapes of the E(t) curves contain information regarding the chemical-physical processes which govern the fate of the substrate during its single passage through the lung. To interpret the shapes, computer simulations are used to illustrate separately the effects of the uptake of substrate into the cell, the returning flux of the substrate from the cell, the saturation phenomena of the extraction process, and the perfusion heterogeneity of the capillaries. Lastly, a simple analytical method for estimating the organ kinetic parameters of the extraction process is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02364055
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...