ISSN:
1432-0428
Keywords:
Angiotensin converting enzyme inhibition
;
enalapril
;
glomerular hyperfiltration
;
diabetic nephropathy
;
glomerular filtration rate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Using a prospective randomised double-blind crossover design, the effect of the angiotensin converting enzyme inhibitor enalapril compared to a placebo was studied in 18 normotensive, normoalbuminuric Type 1 (insulin-dependent) diabetic children. Each patient had a high normal or clearly elevated glomerular filtration rate (145 ml· min−1· 1.73 m2 or higher) in the 6 months prior to the study. Enalapril, 0.5 mg·kg−1· day−1, was given for 4 weeks followed by placebo for 4 weeks, or vice versa. At the end of each period, glomerular filtration rate, renal plasma flow, blood pressure, plasma renin activity, and converting enzyme activity were determined. Enalapril caused significant reduction (p=〈0.001) in blood pressure and converting enzyme activity and a rise in plasma renin activity. A slight but not significant rise in glomerular filtration rate and renal plasma flow without change in filtration fraction was observed. These data suggest that the renin angiotensin system is not involved in the glomerular hyperfiltration of Type 1 diabetes, and can be interpreted as showing no evidence for the presence of intraglomerular hypertension in these patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00285294
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