ISSN:
1432-2072
Keywords:
Vasopressin
;
Desamino-d-arg8-vasopressin
;
Alcohol
;
Ethanol
;
Vigilance
;
Attention
;
Humans
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract It has been suggested that vasopressin (VP) and its analogues such as desamino-d-arg8-vasopressin (DDAVP) affect cognitive (including mnemonic) and attentional processes in man. We describe the effects of DDAVP and ethanol (EtOH) on young, healthy human volunteers, using a recently developed visual search task which assesses attention and vigilance. Over a 1-h session, the subject has to detect the occurrence of certain digits in a long list of random characters. A low dose of EtOH (0.33 ml/kg) tended to improve, and a higher dose (1.0 ml/kg) disrupted performance. DDAVP (20 or 60 μg/subject) had no effect whatsoever. It is concluded that intranasal administration of the peptide analogue does not markedly affect attention performance in human subjects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00172872
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