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  • 1
    ISSN: 1437-1596
    Keywords: Bloodstains species identification ; Species identification, immunoassay (ELISA) ; Blutspuren, Antigeneigenschaften ; Speziesidentifikation, Immunoassay (ELISA)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Antigeneigenschaften von Blutspuren menschlicher und nichtmenschlicher Primaten und anderer Tiere wurden mit Hilfe des Inhibitions-ELISA unter Benutzung käuflich erhältlicher Anti-Human-Albumin-und Anti-Alpha2-makroglobulin-, Fibrinogen-, Transferrin- und IGG-Seren untersucht. Allgemein kann festgestellt werden, daß Blutspuren von Schimpansen die stärksten Kreuzreaktionen mit diesen Antiseren aufwiesen und daß das Ausmaß der Kreuzreaktionen von Blutspuren anderer Tiere deutlich in Verbindung mit dem phylogenetischen Rang, wie folgt, abnahm: agiler Gibbon, Hundsaffen (Japanischer Affe, Mantelpavian), Breitnasenaffen (Nachtaffen und Kapuziner), Halbaffen (Groß-Galago und Katta) und andere Tiere (Ratte, Rind, Schwein, Ziege, Hund, Katze und Huhn). Unter diesen Antiseren zeigten Anti-Human-Alpha2-Makroglobulin-Seren die schwächsten Kreuzreaktionen mit Blutspuren von Schimpansen; Anti-HumanAlbumin folgte hiernach.
    Notes: Summary Antigenic properties of bloodstains of human and non-human primates as well as other animal bloodstains were investigated by the inhibition ELISA using commercially available anti-human albumin (Alb), α2-macroglobulin (α2-M), fibrinogen, transferrin, and immunoglobulin G. In general, chimpanzee bloodstains showed strong cross-reactions with these antisera, and the extent of the cross-reactions of other animal bloodstains decreased largely with the phylogenic order, i.e., agile gibbon (ape), Old World monkeys (Japanese monkey and hamadryas baboon), New World monkeys (night monkey and tufted capuchin monkey), prosimians (grand galago and ring-tailed lemur) and other animals (rat, cattle, swine, goat, dog, cat, and chicken). Among these antisera, anti-human α2-M showed the weakest cross-reaction with chimpanzee bloodstains, and anti-human Alb showed next.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European archives of oto-rhino-laryngology and head & neck 243 (1986), S. 242-245 
    ISSN: 1434-4726
    Keywords: Hyperlipoproteinemia ; Auditory dysfunction ; Cochlea ; Histochemistry ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We sought to clarify whether or not hyperlipoproteinemia induces auditory dysfunction. In so doing, we studied the general states and cochlear pathologies of guinea pigs after the administration of a hyperlipid diet for 3 months. Serum biochemistries indicated marked elevations of cholesterol, high density lipoprotein (HDL)-cholesterol and low density lipoprotein (LDL) levels. An increased auditory threshold varying from 10 to 20 dB was observed in 40% of the guinea pigs using auditory brainstem responses. Histochemical study of the inner ear revealed variations in lipid metabolism and partial disorders of the outer hair cells. Electron microscopic observations showed vacuolar and parenchymal protrusions on the surfaces of the stria vascularis and Corti's organ, and vacuolar degeneration was seen around the capillary vessels of the vascular stria. Our data has shown that the auditory dysfunction present in the inner ear was less marked than were the morphological changes seen. Our findings suggest that other factors besides hyperlipoproteinemia are involved in the development of severe auditory damage.
    Type of Medium: Electronic Resource
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