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  • 1985-1989  (4)
  • 1890-1899  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The Physiology of B Cells as Studied with Tumor Models (1986)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Immunology 4 (1986), S. 621-649 
    Details
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.iy.04.040186.003201
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Isolation of α-tubulin genes from the human malaria parasite, Plasmodium falciparum: sequence analysis of α-tubulin (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 3 (1989), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: As a step towards indentifying exploitable differences between host and parasite at the molecular level, we have isolated and sequenced genomic clones encompassing an entire α-tubulin gene (designated α-tubulin I) from the human malaria parasite, Plasmodium falciparum. The gene, which contains two introns, encodes a product with a predicted length of 453 amino acid residues (50.3 kD). The protein sequence shows a high degree of homology to other α-tubulins, particularly that of the coccidian parasite, Toxoplasma gondii (94%), whose gene carries introns in identical positions. Only one copy of the α-tubulin I gene itself was found, although a second gene designated α-II was also identified which is closely related but which differs at both the nucleotide and amino acid sequence levels. The α-I and β-tubulin genes were found to reside on different chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1989.tb00136.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cloning of a β-tubulin gene from Plasmodium falciparum (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 3 (1989), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: We describe the isolation and characterization of a gene for β-tubulin from the malaria parasite, Plasmodium falciparum. This organism appears to contain a single gene encoding β-tubulin. A single transcript from this gene can be detected in the total RNA of the parasite's asexual blood stages. The complete sequence for the gene has been elucidated. It has two introns, one of which has a position identical to that of a related parasite, Toxoplasma gondii. The gene shows the usual preference for codons with A or T in the third position. The predicted amino acid sequence is compared with that of T. gondii and the human host. Further comparisons between these and fungal sequences of β-tubulins resistant to benomyl, a drug binding this protein, highlight differences that could be exploited in the development of parasite-specific anti-tubulin drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1989.tb00137.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Verhandlungen der American Dermatological Association 1898 (1899)
    Springer
    Archives of dermatological research 49 (1899), S. 386-398 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01977058
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Circling behavior in mice and rats: possible relationship to isolation-induced aggression (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 329-331 
    Details
    ISSN: 1420-9071
    Keywords: Rotation ; isolation ; conspecific aggression ; muricide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The relationship between circling behavior (rotation), isolation, and aggression was investigated in normal male mice and rats. Initially the animals were tested for spontaneous nocturnal rotation, then conspecific aggression and muricidal behavior was observed for mice and rats respectively. Subsequently, animals were paired on the basis of net nocturnal rotations and either group-housed or individually housed. Four weeks later all animals were retested for the same behaviors. Spontaneous nocturnal rotation increased significantly for the isolated mice but not for the group-housed animals. Moreover, 9 of the 10 isolates became aggressive and their net rotations were significantly and positively correlated with the number of biting attacks. None of the group-housed mice became aggressive. Rats, on other hand, showed a decrease in rotation and a relationship between rotation and muricidal behavior was not evident. The possible relationship between circling behavior, aggression, and territoriality is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02004494
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    Paper (German National Licenses)
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