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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 49 (1987), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effects of substance P on the functioning of nicotinic acetylcholine receptors in PC12 cells were examined. Carbachol-stimulated 22Na+ uptake was used to assess the functional state of the nicotinic receptor. We found that incubation of the cells with substance P alone caused a loss of receptor function. Receptors recovered from this effect with a t1/2 of 0.94 ± 0.10 min. Since receptors recovered from carbachol-induced desensitization at a significantly slower rate (t1/2, 1.77 ± 0.21 min), it was concluded that the two inactive states are not kinetically equivalent. The effects of substance P on carbachol-induced loss of receptor activity were also examined. Substance P had no effect on a component of carbachol-induced loss of activity that was non re-coverable (inactivation). However, substance P had several effects on the recoverable loss of activity induced by carbachol (desensitization). Substance P caused a shift to the left in the EC50 for carbachol-induced desensitization at equilibrium. If cells were simultaneously incubated with carbachol and substance P7-11, a low-potency analog of substance P, an increase in the rate of formation of a state of the receptor that was kinetically indistinguishable from the state induced by carbachol alone was observed. However, not all inhibition of nicotinic cholinergic function could be explained by an increased rate of formation of a desensitized receptor and it is concluded that substance P causes both enhanced desensitization and block of the nicotinic receptor-linked channel.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 24 (1985), S. 966-970 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 26 (1987), S. 228-236 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 1 (1989), S. 1757-1757 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The questions raised in the comment by Hirose are answered.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 29 (1986), S. 1744-1746 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new type of frequency dependence caused by an outgoing boundary condition has been found in the dispersion relation for ballooning modes. The new, simple dispersion relation has been found for the first time to give growth rates in excellent agreement with numerical results for small values of shear. The analytical stability condition has been improved.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 28 (1985), S. 1359-1365 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new branch of magnetohydrodynamic ballooning modes is shown to be destabilized by energetic trapped particles. Both the real frequencies and growth rates of the instabilities are comparable to the trapped-particle precession frequencies. The theoretical results are also shown to be consistent with the high-frequency (∼100 kHz) oscillations observed during the high-power beam-injection experiments in the tokamak experiment PDX.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 31 (1988), S. 2233-2237 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Four coupled nonlinear evolution equations for the electrostatic potential, the density fluctuation, and the two vector potentials are derived from the two-fluid and Maxwell's equations that describe low-frequency collisionless finite-beta inhomogeneous plasmas. Under the assumption of weak turbulence, the above equations reduce to the nonlinear Schrödinger equation. The technique adopted here is considered as an extension of the formal Karpman–Krushkal [Sov. Phys. JETP 28, 277 (1969)] method to a system of nonlinear partial differential equations. The general exact traveling wave solution to the nonlinear Schrödinger equation is obtained with the help of the Hamilton–Jacobi theory. This general solution may be regarded as describing a final nonlinear stage of the modulational instability. It is also shown that a solitary wave solution to the nonlinear Schrödinger equation, which corresponds to the limiting case of the general solution, is given by means of the simple iterative method.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 31 (1988), S. 359-365 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A comparatively complete two fluid description of collisionless electromagnetic ballooning modes has been derived. Using an unexpanded ion density response, it has been shown for the first time using a fluid theory that a necessary and sufficient condition for an instability of the magnetohydrodynamic (MHD) branch below the MHD beta limit is the presence of an ion temperature gradient exceeding a threshold. The cause of this instability has been identified and an analytical dispersion relation is given.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 31 (1988), S. 2228-2232 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A simplified nonlinear gyrokinetic formalism has been developed for general distribution functions and general magnetic perturbations. It has been found that the nonlinear coupling strength for low frequency electromagnetic modes in plasmas with anisotropic temperature is larger than for the isotropic case for small Larmor radius. A nonlinear cascade where the pump mode is the mode with intermediate parallel phase velocity has been found.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 28 (1985), S. 1735-1738 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: It is found that an electromagnetic analog of the current convective instability in the nonlinear regime may develop into a chaotic system. Comparison is made with the corresponding electrostatic strongly nonlinear case which may show chaotic behavior of the Lorenz type, and the nonlinear cascade properties are discussed.
    Type of Medium: Electronic Resource
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