ISSN:
1432-1912
Keywords:
Dopamine receptors
;
3H-N-propyl-norapomorphine
;
Discriminant dopamine antagonists
;
Striatum
;
Tuberculum olfactorium
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The in vivo accumulation of 3H-N-propyl norapomorphine in mouse striatum and tuberculum olfactorium and its inhibition by a series of classical neuroleptics and discriminant benzamide derivatives previously identified in behavioural and radioligand experiments has been studied. The ID50 values in the two brain areas did not significantly differ with any studied compound. In addition the regional distribution of a discriminant compound related to sulpiride and administered in tritiated form to rats was rather homogeneous. These data do not indicate a preferential accumulation of these compounds in limbic as opposed to striatal areas.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00501199
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