ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

The aortic alpha1-adrenergic receptor in familial amyloidotic polyneuropathy (1988)

Azuma, T. ; Watanabe, Y. ; Suzuki, T. ; [et al.]

Springer

Journal of neural transmission 73 (1988), S. 23-30

add to mindlist on the mindlist

Details

ISSN: 1435-1463

Keywords: Familial amyloidotic polyneuropathy ; aorta ; alpha1-adrenergic receptor ; 3H-bunazosin

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary To assess the pathophysiology of the sympathetic nervous system in familial amyloidotic polyneuropathy (FAP), we used3H-bunazosin to identify and characterize the alpha1-adrenergic receptor in human aortic membranes. The binding of3H-bunazosin was rapid, readily reversible, stereospecific, and saturable. The Scatchard analysis described a single class of binding sites with a dissociation constant (KD) of 0.370±0.035nM and a maximal binding capacity (Bmax) of 11.8±1.30 fmol/mg protein in control patients. Competition analysis demonstrated the alpha1-adrenergic specificity of the3H-bunazosin binding sites in human aortic membranes. The KD and Bmax of3H-bunazosin binding in four FAP patients was 0.274±0.052 nM and 7.79±0.15 fmol/mg protein, respectively; these values did not differ significantly from those in 14 control patients. An increase in Bmax or affinity of alpha1-adrenergic receptors may not be the cause for denervation supersensitivity in FAP.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01244619

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Quantitative surface chemical analysis of Au—Cu alloys with aes (1988)

Yoshihara, K. ; Shimizu, R. ; Homma, T. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

Surface and Interface Analysis 12 (1988), S. 125-130

add to mindlist on the mindlist

Details

ISSN: 0142-2421

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Physics

Notes: The Japanese VAMAS-SCA working group is composed of 19 institutes. Three kinds of Au-Cu alloys (Au25 at%-Cu75 at%, Au50 at%-Cu50 at%, Au75 at%-Cu25 at%) were prepared, and these specimens were distributed to the members of Japanese VAMAS-SCA working group and Auger peak amplitude ratios were measured to clarify the correlation factor of different types of spectrometers. The comparison was carried out by using the relative sensitivity factor for Au and Cu. The relative sensitivity factor for lower energy varied from spectrometer to spectrometer, but that for higher energy did not vary so much. Therefore, to carry out the inter-laboratory comparison of the data, the transfer of the data of peak amplitude at higher energy should be recommended.

Additional Material: 5 Ill.