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6-Thioguanine: High-dose 2-H infusions in goats (1985)

Schouten, Teunis J. ; Abreu, Ronney A. ; Schretlen, Egbert D. A. M. ; [et al.]

Springer

Journal of cancer research and clinical oncology 110 (1985), S. 115-118

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ISSN: 1432-1335

Keywords: 6-Thioguanine ; 6-Thioguanosine ; 6-Thioguanine riboside ; 6-Mercaptopurine ; Thiopurines

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary 6-Thioguanine (6TG) is poorly absorbed after oral administration. Bolus injections of 6TG result in high peak concentrations with relatively shortlived plasma concentrations. In vitro studies have shown the importance of prolonged exposure to 6TG. Therefore we administered 6TG by infusion at a dose rate of 2 mg/h over 2 h. In three goats we determined the plasma concentration-time curves of 6TG and its riboside (6TGR). A steady state was reached for 6TG and was almost reached for 6TGR within the 2 h of infusion. In one experiment we obtained several samples of CSF and observed good penetration of 6TG and 6TGR into CSF. Urinary excretion of 6TG and 6TGR was also quantitated. The amount of drug and metabolite excreted later than 4 h after the end of the infusion was negligible. By infusing 6TG, the problems of both erratic absorption after oral administration and acute renal toxicity after bolus injection, can be averted. In our opinion prolonged infusions of 6TG may be of advantage in humans suffering from actively proliferating malignant diseases, and thus should be studied.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00402722

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Localization of basic fibroblast growth factor to the developing capillaries of the bovine retina (1989)

Hanneken, Anne ; Lutty, Gerard A. ; McLeod, D. Scott ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Cellular Physiology 138 (1989), S. 115-120

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ISSN: 0021-9541

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: The basic fibroblast growth factor (FGF) is a potent mitogen that has vascular endothelium as one of its principle target cells. Recent work has provided both the complete amino acid sequence of basic FGF and the nucleotide sequence of the genes for both human and bovine basic FGF. Although capillary endothelial cells have been shown to produce basic FGF in vitro and to deposit basic FGF in their extracellular matrix in vitro as well, no direct evidence yet exists for the distribution of basic FGF in vivo. Antipeptide antibodies were prepared against a 15-amino-acid sequence from the amino terminus of basic FGF in order to avoid cross-reactivity with acidic FGF, a protein with 55% overall homology to basic FGF. After affinity purification, these antisera were used to localize the basic fibroblast growth factor in the fetal and adult bovine retina. Immunoreactive material was found in capillaries of the inner nuclear layer, a capillary network undergoing development during the third trimester in the fetal bovine eye. Although the resolution of the technique does not permit a unique assignment of cellular localization, the presence of stain immediately adjacent to the lumen of capillaries suggests that capillary endothelial cells may produce the basic fibroblast growth factor in vivo during vascular development.

Additional Material: 6 Ill.