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  • 1985-1989  (2)
  • cytochrome P-450  (2)
  • 7-alkoxycoumarin  (1)
  • 7-propoxycoumarin  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Cytochrome P-450 mediated O-dealkylation of 7-alkoxycoumarins in liver microsomes from rainbow trout (Salmo gairdneri) (1989)
    Springer
    Fish physiology and biochemistry 6 (1989), S. 199-205 
    Details
    ISSN: 1573-5168
    Keywords: cytochrome P-450 ; β-naphthoflavone ; 7-alkoxycoumarin ; 7-methoxycoumarin ; 7-ethoxycoumarin ; 7-propoxycoumarin ; 7-butoxycoumarin ; fish ; rainbow trout ; liver microsomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Evidence has recently been presented for variation in the inducibility of various 7-alkoxycoumarin-O-dealkylase activities in liver microsomes from a number of mammalian species by β-naphthoflavone (βNF). In the present study we have investigated the inducibility of hepatic microsomal 7-methoxycoumarin-O-demethylase, 7-ethoxycoumarin-O-deethylase, 7-propoxycoumarin-O-depropylase and 7-butoxycoumarin-O-debutylase activities in rainbow trout by βNF. O-demethylase activity was increased approximately 17-fold, O-deethylase and O-depropylase activities approximately 9-fold and O-debutylase activity approximately 25-fold. The kinetics of the various hepatic microsomal 7-alkoxycoumarin-O-dealkylase activities were investigated in control and βNF-treated rainbow trout. The O-demethylase-, O-depropylase- and O-debutylase activities exhibited monophasic Michaelis-Menten kinetics in liver microsomes from both control and βNF-treated rainbow trout, whereas the O-deethylase activity exhibited biphasic Michaelis-Menten kinetics in control liver microsomes and monophasic Michaelis-Menten kinetics in liver microsomes from βNF-treated rainbow trout.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01875022
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Cytochrome P-450-dependent metabolism in isolated liver cells from fed and starved rainbow trout,Salmo gairdneri (1986)
    Springer
    Fish physiology and biochemistry 1 (1986), S. 105-111 
    Details
    ISSN: 1573-5168
    Keywords: xenobiotic metabolism ; cytochrome P-450 ; isolated liver cells ; starvation ; rainbow trout ; fish
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The cytochrome P-450 content in liver cells from rainbow trout was not affected by starvation for 12 weeks whereas the rate of cytochrome P-450-dependent deethylation of 7-ethoxycoumarin in liver cells from 6 or 12 weeks starved fish was 60% of the rate in fed fish. Treatment of fish with β-naphthoflavone increased the 7-ethoxycoumarin metabolism several-fold in both starved and fed fish. Optimal cytochrome P-450 monooxygenation in liver cells from fed or starved fish was not affected by addition of glucose or 2-bromooctanoate, an inhibitor of fatty acid β-oxidation which is the main source of metabolic fuel in trout liver. The cellular content of NADPH, an obligatory cofactor for cytochrome P-450 monooxygenation, was not affected by addition of substrate to cytochrome P-450, inhibition of fatty acid β-oxidation or inhibition of the oxidative phosphorylation. This indicates a great capacity of rainbow trout liver cells to retain high NADPH/NADP+ ratios. These results suggest that the cytochrome P-450 mediated metabolism of xenobiotics in liver cells from fed or starved trout is not limited by the availability of reducing equivalents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02290210
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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