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  • 1985-1989  (3)
  • Acute myelofibrosis  (1)
  • Calcitonin  (1)
  • Chemotherapy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Acute myelofibrosis in megakaryoblastic leukemia with translocation between chromosomes 8 and 14 (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 1034-1041 
    Details
    ISSN: 1432-1440
    Keywords: Acute myelofibrosis ; Megakaryoblastic leukemia ; Platelet peroxidase ; Cytogenetics ; β-Thromboglobulin ; Flow cytometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a 45-year-old woman with severe normochromic anemia (Hb 2.8 g%) an extensive myelofibrosis and infiltration of the bone marrow with small blasts was observed histologically. Cytochemical examination of the blasts showed a negative peroxidase and a strongly positive alpha-NE reaction. PAS reaction was slightly granular positive in the cytoplasmic protuberances of the blasts and in the platelets. Marker analysis yielded no evidence of lymphatic origin of the blasts. In flow-cytometric studies of 230,000 cells a homogeneous 2c blast population could be identified. Cytogenetic analysis revealed an abnormal pseudo-diploid karyotype characterized by 2 acrocentric marker chromosomes caused by a translocation of chromosomes 8 and 14, as usually seen in Burkitt type lymphoma. Finally the reaction product of platelet-specific peroxidase could be demonstrated in the perinuclear cisternae of the endoplasmic reticulum by electron microscopy. Highly elevated β-thromboglobulin and platelet factor 4 plasma levels were also measured. Following an ineffective treatment with daunoblastine and ARA-C, the patient died of pseudomonas aeruginosa septicemia after having received high-dose ARA-C treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726322
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Calcitonin gene products and the kidney (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 870-875 
    Details
    ISSN: 1432-1440
    Keywords: Calcitonin ; Calcitonin gene-related peptide ; Renovascular effects ; Renotubular effects ; Renin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation. Systemic infusion of CGRP and perfusion of isolated rat kidney reduces vascular resistance, and increases renal blood flow and glomerular filtration. CGRP stimulates renin secretion in vivo and in vitro and inhibits contraction of isolated rat mesangial cells by angiotensin II. Calcitonin does not affect vascular resistance, renal blood flow and glomerular filtration, and is less potent in stimulating renin secretion, and does not alter contraction of isolated rat mesangial cells by angiotensin II. CGRP also exerts renal tubular effects brought about probably through interaction with calcitonin receptors. To this end, increased excretion of sodium and chloride, and stimulation of urinary flow are less pronounced with CGRP than with calcitonin. Calcitonin, moreover, stimulates the fractional urinary excretion of calcium and phosphate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717342
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Polychemotherapy of acute myelogenous leukemia in a patient with acute intermittent porphyria (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 338-340 
    Details
    ISSN: 1432-1440
    Keywords: Porphyria ; Chemotherapy ; Acute myelogenous leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The safety of drugs in hepatic porphyrias has largely been established by clinical experience, which is very limited in the case of antineoplastic agents. We administered three cycles of polychemotherapy consisting of daunorubicin, cytarabine and 6-thioguanine, and modified supportive care to a 33-year-old Turkish woman suffering from acute myelogenous leukemia. The urinary excretion of total porphyrins, porphobilinogen, and aminolevulinic acid was continuously monitored. Excreation of these metabolites was permanently elevated, but the values were comparatively low during cytotoxic therapy while peak values were recorded at the onset of fever during bone marrow aplasia; yet there were no clinical signs of porphyritic attacks at that time. A few potentially unsafe drugs were tolerated without an increase in porphyrin excretion. Although the susceptibility to drugs is highly variable in patients with hepatic porphyrias, the treatment of malignancy in these patients seems justified as long as porphyrin excretion under therapy is not grossly elevated over baseline values and appropriately modified supportive care is administered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01745391
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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