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  • 1
    Electronic Resource
    Electronic Resource
    Chelation in metal intoxication XVII: antidotal efficacy of polyaminocarboxylic acids on acute chromate toxicity (1985)
    Springer
    Archives of toxicology 57 (1985), S. 212-213 
    Details
    ISSN: 1432-0738
    Keywords: Chromate ; Acute toxicity ; Polyaminocarboxylic acids ; Mortality protection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Some polyaminocarboxylic acids containing amino and carboxyl groups as metal binding sites in different structural arrangements were evaluated for their relative efficacy in protecting against acute chromate intoxication in mice. Nitrilotriacetic acid (NTA) and 1,2 cyclohexylenediamine tetraacetic acid (CDTA) were most effective in preventing mortality (50–70%) due to a lethal dose of potassium chromate at one-tenth of their respective LD50.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00290890
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of thiamine and ascorbic acid supplementation on the antidotal efficacy of thiol chelators in experimental lead intoxication (1988)
    Springer
    Archives of toxicology 62 (1988), S. 301-304 
    Details
    ISSN: 1432-0738
    Keywords: Lead ; Thiamine ; Ascorbic acid ; Chelation ; α-Mercapto-β-(2-furyl) acrylic acid ; 2,3-Dimercaptosuccinic acid ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of the administration of thiamin (vitamin B1), ascorbic acid (vitamin C) or their combination on the efficacy of two thiol metal chelators, viz. α-mercapto-β-(2-furyl) acrylic acid (MFA) and 2,3-dimercaptosuccinic acid (DMS), in counteracting lead (Pb) toxicity was investigated in rats. Ascorbic acid or its combination with thiamine enhanced the urinary elimination of Pb, reduced the hepatic and renal burden of Pb, and reversed the Pb-induced inhibition of the activity of blood 5-aminolevulinic acid dehydratase (δ-ALA-D). All these effects were more evident in DMS- than in MFA-treated rats. The combination of MFA and DMS treatments further improved the performance of the animals in enhancing urinary Pb excretion and in reducing Pb hepatic levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332491
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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