ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated byβ protein immunostaining (1988)

Yamaguchi, H. ; Hirai, S. ; Morimatsu, M. ; [et al.]

Springer

Acta neuropathologica 76 (1988), S. 541-549

add to mindlist on the mindlist

Details

ISSN: 1432-0533

Keywords: β Protein ; Senile plaques ; Amyloid ; Alzheimer ; Dementia

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary We studied cerebral amyloid deposits in the hippocampal area immunohistochemically, using antiserum to syntheticβ peptide (1–28) in 66 patients with or without dementia and aged 17 to 91 years old. Senile plaques (SP) and amyloid angiopathy (AA) were detected in 36 (55%) and 19 (29%) patients, respectively. Also, cerebral amyloid deposits from the brains of seven patients with dementia and five patients without were studied in serial sections stained with Bodian, modified Bielschowsky, Congo red, andβ protein immunostain. In the patients with Alzheimer-type dementia (ATD) diffuse plaques, typical of this group, were stained withβ protein antiserum but not with Bodian stain, because the plaques were devoid of abnormally swollen neuritic processes. The diffuse plaques often contained one or more neuronal cell bodies. As well as primitive and classic plaques and AA, theβ protein immunostain demonstrated small deposits among the SP, small stellate deposits of layer 1, subpial fibrillar deposits, and focal cribriform deposits of parasubiculum, which may be new types of amyloid deposits. Amyloid plaques within the subcortical white matter were only found in ATD brains. In the non-demented patients various kinds of SP, including diffuse and compact ones, were immunostained. They tended to be small and few.β protein immunostain with formic acid pretreatment is a useful method for the identification of a variety of senile cerebral amyloid deposits.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00689591

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Effects of static magnetic fields on diffusion in solutions (1988)

Kinouchi, Y. ; Tanimoto, S. ; Ushita, T. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Bioelectromagnetics 9 (1988), S. 159-166

add to mindlist on the mindlist

Details

ISSN: 0197-8462

Keywords: Lorentz force ; Maxwell stress ; threshold field strength ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Physics

Notes: Static magnetic fields affect the diffusion of biological particles in solutions through the Lorentz force and Maxwell stress. These effects were analyzed theoretically to estimate the threshold field strength for these effects. Our results show that the Lorentz force suppresses the diffusion of charged particles such as Na+, K+, Ca2+, Cl-, and plasma proteins. However, the threshold is so high, i.e., more than 104 T, that the Lorentz force does not affect the ion diffusion at typical field strengths (a few Tesla at most). Since the threshold of gradient fields for producing a change in ion diffusion through the Maxwell stress is more than 105 T2/m for paramagnetic molecules (FeCl3, O2) and plasma proteins, their diffusion would be unaffected by typical gradient fields (100 T2/m at most) and even by high gradient fields (less than 105 T2/m) used in magnetic separation techniques. In contrast, movement of deoxygenated erythrocytes and FeCl3 colloids (more than 103 molecules) is influenced by the usual gradient fields due to a volume effect.

Additional Material: 1 Ill.