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Comparison among five mutagenicity assays in workers producing polyurethane foams (1988)

Holmén, A. ; Åkesson, B. ; Hansén, L. ; [et al.]

Springer

International archives of occupational and environmental health 60 (1988), S. 175-179

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ISSN: 1432-1246

Keywords: Isocyanates ; Amines ; Occupational exposure ; Cytogenetic testing ; Mutagenic assays

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Thirty-two male individuals exposed to isocyanates and amines during the production of plastic foams and 20 male referents were studied by cytogenetic methods (chromosomal aberrations, sister chromatid exchanges and micronuclei in lymphocytes) and by urinary mutagenic assays (thioether concentrations and mutagenic activity with Salmonella TA98 and E. Coli WP2 uvrA). The occupational exposure was monitored by measurements of toluene diisocyanate and N-methylmorpholine in work-room air. The levels were below the current Swedish hygienic standards. Although all parameters, except the sister chromatid exchanges, showed increased mean values for the exposed group compared to the referents, only the urinary thioether concentrations differed significantly. The study was, however, non-conclusive with regard to a genetic effect of the occupational exposure as measured by the cytogenetic parameters. This may be due to the low exposure level. In the micronuclei frequencies there was a significant effect of age. Smoking significantly affected the SCE frequencies, the thioether concentrations and the mutagenic activities in the Salmonella assay. There were statistically significant correlations between the urine specimens collected during one working day and the following morning with regard to the mutagenic activities in the Salmonella and E. coli assays, and in the thioether concentrations as well. The association between the different cytogenetic and urinary mutagenic assays were weak but there were several statistically significant correlation coefficients, indicating that the variables may have a common metabolic background.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00378694

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Vibrational spectra, phase transitions and conformers of 1,4-dichlorobut-2-yne (1987)

Karlsson, A. ; Klaeboe, P. ; Nielsen, C. J.

Chichester [u.a.] : Wiley-Blackwell

Journal of Raman Spectroscopy 18 (1987), S. 461-471

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ISSN: 0377-0486

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Notes: The Raman and IR spectra of 1,4-dichlorobut-2-yne (DCB) as a liquid at various temperatures and as an amorphous and as metastable and stable crystalline solids at low temperatures have been recorded in the 4000-20 cm-1 range. Additional IR and Raman spectra of a high-pressure crystalline phase were obtained at ca 17 kbar pressure.The broad unsymmetrical bands of DCB in the liquid and in the amorphous solid below 500 cm-1 suggest nearly free rotation in these phases at all of the temperatures investigated. Below ca 190 K a crystal containing the anti and above 190 K a crystal containing the gauche conformer of DCB were formed; the latter crystal is believed to be thermodynamically more stable at all temperatures. Only one high-pressure crystal with molecules in the anti conformation was formed at room temperature. A phase transition reported at 232 K in the liquid, involving a conversion to an anti conformer, was not detected.Complete vibrational assignments for both anti and gauche conformers are presented, supported by force constant calculations.

Additional Material: 10 Ill.