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Cerebral amyloid angiopathy in the aged (1987)

Yamada, M. ; Tsukagoshi, H. ; Otomo, E. ; [et al.]

Springer

Journal of neurology 234 (1987), S. 371-376

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ISSN: 1432-1459

Keywords: Cerebral amyloid angiopathy ; Ageing ; Amyloid protein ; Dementia ; Lobar cerebral haemorrhage

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Cerebral amyloid angiopathy (CAA) was found in 57% of 123 autopsy brains removed from patients aged 59–101 years. The incidence of CAA increased with age. CAA was seen most frequently in the occipital cortex. Immunohistochemically, amyloid of CAA was positive for amyloid P component and negative for human AA protein and human prealbumin. The presence and severity of CAA were significantly correlated with the number of senile plaques and neurofibrillary tangles. The incidence of CAA in 17 patients with dementia of Alzheimer type (DAT) was estimated to be 88% and was significantly higher than that in 26 patients with dementia of non-Alzheimer type. CAA had a pathogenetic relationship with both brain ageing and DAT. Lobar cerebral haemorrhage was found in 3 patients with CAA of marked or moderate degree. Lobar cerebral haemorrhage in the aged and in patients with DAT suggest the presence of CAA.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00314080

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Determination of metabolites relating to the tryptophan-NAD pathway in rat urine by cellulose high performance thin-layer chromatography (1985)

Yamada, M. ; Minami, Y. ; Yuyama, S. ; [et al.]

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 8 (1985), S. 69-72

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ISSN: 0935-6304

Keywords: Thin-layer chromatography, HPTLC ; Cellulose plates ; Tryptophan-NAD pathway ; Rat urine ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: High performance thin-layer chromatography (HPTLC) was used to determine 12 metabolites of the tryptophan-NAD pathway in rat urine. The method of separation described in the previous report was improved. The metabolites were separated on the cellulose plate by using five multiple developments with four solvent systems. The plate was scanned by the TLC scanner at 254 nm and the amounts of the metabolites were calculated by comparing peak areas of the scanning curves obtained for the urine sample and for the authentic standards. This procedure can be used as a semiquantitative determination method for the metabolites in biological fluids.

Additional Material: 1 Ill.