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  • 1985-1989  (2)
  • Anti-insulin  (1)
  • chemical structure/irritation  (1)
  • Autoimmunity
  • Thyrotropin receptor
  • 1
    Electronic Resource
    Electronic Resource
    Semi-quantitative assessment of anti-insulin total IgG and IgG sub-classes in insulin-immunized patients using a highly sensitive immunochemical micromethod (1986)
    Springer
    Diabetologia 29 (1986), S. 720-726 
    Details
    ISSN: 1432-0428
    Keywords: Anti-insulin ; IgG sub-classes ; monoclonal antibodies ; enzyme linked immunosorbant assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunochemical micromethod was designed to estimate total IgG and IgG sub-classes of anti-insulin antibodies in immunized diabetic patients. Insulin, immobilized on a solid phase, was allowed to react with serum samples containing anti-insulin antibodies. Bound anti-insulin IgG interacted with mouse monoclonal antibodies specific for total IgG or for each IgG isotype. The fixation of mouse monoclonal antibody was subsequently detected using a horseradish peroxidase-conjugated rabbit anti-mouse IgG in the presence of a chromogenic substrate. The test was standardized by an immunocapture assay utilizing coated rabbit anti-human IgG and known concentrations of purified human myelomatous proteins of each sub-class. Results of anti-insulin IgG and anti-insulin IgG sub-classes assay could therefore be expressed in ng equivalent myelomatous proteins per ml of serum. Analysis of serum samples from 24 insulin-immunized diabetic patients revealed a quasi absence of IgG2 anti-insulin antibodies and an increase of the relative abundance of the other three anti-insulin IgG isotypes. In our series, anti-insulin IgG1 was predominant, followed by IgG3 (in 17/24 patients) or IgG4 (in 7/24). Insulin immunization was deduced to be of polyclonal nature, the isotype pattern of which is not representative of the relative proportion of IgG sub-classes in whole normal serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870282
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The Relationship of pK a and Acute Skin Irritation in Man (1988)
    Springer
    Pharmaceutical research 5 (1988), S. 660-663 
    Details
    ISSN: 1573-904X
    Keywords: skin irritation ; pK a ; pH, skin permeation ; chemical structure/irritation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The relationship between pK a and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15–88 µg/cm2/hr). Skin irritation and pK a are correlated for pK a ≤ 4. Laser Doppler velocimetric assessment of skin blood flow, color meter readings, erythema, edema, and the primary irritation index are all linearly correlated and related to pK a, erythema at 24 hr appears to be the most sensitive parameter to variation in pK a when pK a ≤ 4.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015931105660
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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