ISSN:
1432-1335
Keywords:
2-Phenylindole
;
Antitumor activity
;
Estrogen-dependent mammary tumors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The antineoplastic activity of 4-chloro-2-(2,6-dichloro-4-hydroxyphenyl)-1-ethyl-6-hydroxyindole (D 15413) was determined in several estrogen-dependent mammary tumor models. The growth of DMBA-induced rat mammary carcinomas was inhibited by doses ranging from 2 to 18 mg/kg. A dose of 6×12 mg/kg per week p.o. reduced the tumor area by 82% (control+192%). D 15413 was also active against MNU-induced rat mammary tumors and transplanted MXT tumors of the mouse. In vitro, the growth of estrogen receptor positive MCF-7 breast cancer cells was inhibited by D 15413 (10−8–10−5 M). A mode of action considering endocrine and cytotoxic effects is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00399276
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