ISSN:
1573-7284
Schlagwort(e):
Campylobacter pylori
;
In-vitro susceptibility
;
Antibiotics
;
Antiulcer drugs
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Forty-nine isolates of Campylobacter pylori were tested for their susceptibility to twenty antibiotics and four anti-ulcer agents by an agar dilution technique. Penicillin and amoxycillin were the most active drugs (MIC90, 0.06 μ/ml); erythromycin, cefazolin, minocycline, ciprofloxacin, ofloxacin and gentamicin were sligthtly less active (MIC90, ≤ 1 μg/ml). Moderate activity was found for doxycyclin, rifampin, nitrofurantoin, norfloxacin, pefloxacin, enoxacin, paromomycin, metronidazole and tinidazole. All strains were resistant to trimethoprim (MIC 〉 512 μg/ml). Nalidixic acid (MIC90, 〉 256 μg/ml) and colistin (MIC90, 〉 64 μgg/m1) had little to no activity. Of four anti-ulcer drugs, only bismuth subcitrate showed activity (MIC90, 64 μg./ml). Strains resistant to all 4-quinolones were found in patients who had previously received ofloxacin as part of a clinical trial aimed at eradication of C. pylori. These isolates remained susceptible to amoxycillin, tetracyclines and to other classes of antibiotics.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00144743
Permalink
