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  • 1985-1989  (4)
  • chemotherapy  (2)
  • Arrhenius behavior  (1)
  • Coronary occlusion  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Microvascular function at the margins of early experimental myocardial infarcts in isolated rabbit hearts (1986)
    Springer
    Heart and vessels 2 (1986), S. 81-86 
    Details
    ISSN: 1615-2573
    Keywords: Ischemia ; Infarct progression ; Reperfusion ; Scanning electron microscopy ; Coronary occlusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Injection of low-viscosity resin was used to identify in situ functional blood vessels at the margins of developing regional myocardial infarcts. The ventral interventricular branch (VIB) of the left coronary artery was occluded for 0–240 min in 20 isolated perfused rabbit hearts. After perfusion fixation with glutaraldehyde, resin was injected into the coronary arteries—that injected into the VIB contained dispersed lead dioxide and that injected into the remainder of the heart contained Fat Red 7B dye. This allowed macroscopic and microscopic identification of functional blood vessels. Following transmural freeze fracture, left ventricles were examined using back-scattered electron imaging in a scanning electron microscope. Close to 60% of capillaries in nonischemic myocardium allowed the passage of resin. Thirty minutes of ischemia produced a hyperemic increase to 80%–90% in the proportion of filled vessels. After 60 min, however, a severe reperfusion defect corresponding to the “no-reflow” phenomenon had developed, with virtually all vessels collapsed and 〈10% functional. Among the structurally normal myocytes adjacent to the infarct margin there was a significant reduction (to 30%–40%) in the proportion of functional capillaries. This was due to groups of dilated vessels which were not accessible to arterial supply. Although these marginal “low-flow” regions were of small volume at any one point in time, they seem likely to contribute to the progression of ischemic necrosis, and are probably nonfunctional due to the compression of their venous drainage traversing the infarct.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02059960
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of stage III breast cancer (1989)
    Springer
    Breast cancer research and treatment 13 (1989), S. 225-235 
    Details
    ISSN: 1573-7217
    Keywords: chemotherapy ; combination therapy ; hormonal synchronization ; locally advanced breast cancer ; preoperative chemotherapy ; prognosis ; radiotherapy ; staging, surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A major question in oncology today concerns the most appropriate therapy for locally advanced breast cancer. Realistic goals include effective local treatment and a prolonged disease-free interval for these patients, most of whom have incurable disease. Here, our panel discusses the roles of surgery, radiation therapy, chemotherapy, and hormonal therapy, and the proper sequencing of these modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02106572
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Adjuvant therapy in node-negative breast cancer (1989)
    Springer
    Breast cancer research and treatment 13 (1989), S. 97-115 
    Details
    ISSN: 1573-7217
    Keywords: adjuvant therapy ; chemotherapy ; clinical trials ; estrogen receptor ; node-negative breast cancer ; prognostic factors ; tamoxifen ; toxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01806522
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The influence of calcium pump coupling on the Arrhenius behavior of sarcoplasmic reticulum Ca2+-ATPase (1987)
    Springer
    Journal of bioenergetics and biomembranes 19 (1987), S. 45-52 
    Details
    ISSN: 1573-6881
    Keywords: Calcium-ATPase ; Arrhenius behavior ; sarcoplasmic reticulum ; ATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract Experiments were performed in which two batches of sarcoplasmic reticulum were isolated from rabbit hind leg muscle, one in the presence of dithiothreitol, the other in the absence of reducing agent. A comparative study was made of some of the properties of the two preparations, in particular, the Arrhenius behavior of the Ca2+-ATPase. The Ca2+-ATPase isolated in the absence of dithiothreitol is thermally unstable with the result that a triphasic Arrhenius plot was obtained. This triphasic behavior is largely the consequence of an uncoupling of the hydrolytic machinery from the calcium pump. In contrast, the sarcoplasmic reticulum preparation obtained in the presence of dithiothreitol is thermally stable and yields a linear Arrhenius plot. The difference in the Arrhenius behavior shown by the two preparations was abolished when the measurements of Ca2+-ATPase activity were made in the presence of the calcium ionophore, A23187.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00769731
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    Paper (German National Licenses)
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