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Digitale Medien

Germanium myopathy: clinical and experimental pathological studies (1989)

Higuchi, I. ; Izumo, S. ; Kuriyama, M. ; [weitere]

Springer

Acta neuropathologica 79 (1989), S. 300-304

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Details

ISSN: 1432-0533

Schlagwort(e): Germanium intoxication ; Vacuolar myopathy ; Mitochondrial abnormality

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Pathological examinations were carried out on the skeletal muscle of a patient with germanium intoxication. The prominent histochemical finding was vacuolar myopathy with lipid excess, increased acid phosphatase activity and decreased cytochrome c oxidase activity. Ultrastructural lesions revealed a mitochondrial abnormality, autophagic vacuoles and accumulation of high electron-dense materials in deformed mitochondria and at the periphery of lipid droplets. Furthermore, the toxic effect of germanium on skeletal muscle was confirmed by the experimentally induced germanium myopathy, which showed autophagic degeneration, decreased cytochrome c oxidase activity and a mitochondrial abnormality with high electron-dense materials.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00294665

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