ISSN:
1432-1912
Keywords:
Skinned cardiac fibres
;
Positive inotropic
;
Calcium release
;
Dihydropyridines
;
BAY K 8644
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary BAY K 8644 is a positive inotropic dihydropyridine which concentration-dependently increased contractile force in guinea-pig atria at 10 to 1000 nmol/l. In chemically skinned cardiac fibres from guinea-pig hearts the substance did not change the tension induced by calcium. Also BAY K 8644 did not release calcium from intracellular myocardial stores like caffeine since it failed to evoke a contractile response in saponin-treated, calcium-loaded cardic muscle. Thus, the drug exerts its effects neither by sensitizing the contractile apparatus to calcium nor by a caffeine-like action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00692904
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