ISSN:
1432-0428
Keywords:
Glucopenia
;
insulin
;
glucagon
;
arginine
;
diabetes
;
BB/W rats
;
perfused pancreas
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To determine if the inhibiting effect of glucopenia on arginine-stimulated insulin secretion is impaired at the onset of autoimmune diabetes, the insulin response to arginine was studied at 5.6 and 2.8 mmol/l glucose in perfused pancreata isolated from BB/W rats on the first day of diabetes and from age-matched diabetes-prone BB/W rats without diabetes. During glucopenia the baseline insulin secretion was reduced by more than 80% in both groups. However, the arginine-stimulated insulin response in the diabetic group was only 16.5% lower during glucopenia compared to 79.1% lower in the nondiabetic controls. Also, enhancement of the arginine-stimulated glucagon response by glucopenia was modest compared to controls. The results indicated that at the onset of this form of autoimmune diabetes the surviving B cells are, for unknown reasons, hyperresponsive to arginine and that, in contrast to the controls, this response is not inhibited by glucopenia.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00290589
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