ISSN:
1432-0533
Keywords:
Isoniazid neuropathy
;
Axonal degeneration
;
Axonal swelling
;
Paranodal demyelination
;
Ventral root
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Morphometric sequential studies of pathologic changes were carried out on myelinated fibers in the lumbar ventral root of Sprague-Dawley rats administered with isoniazid, 1,500 mg/kg body weight, in a single dose. Accumulation of axoplasmic organelles with secondary paranodal retraction of myelin sheath occurred in the middle part of the ventral root as early as day 2 after the administration. On day 3, axonal degeneration started to occur, distal to the middle part, where the accumulation of axoplasmic organelles is prominent. Such accumulation with the possible blockade of the fast axoplasmic transport in the proximal axon may be directly responsible for the distal axonal degeneration. Alternatively such accumulation may be secondary to the distal axonal degeneration. The morphological sequential findings described clearly reflects the pathological events in isoniazid neuropathy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00687801
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