ISSN:
0173-0835
Keywords:
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
An ultrathin-layer polyacrylamide gel isoelectric focusing method is described for typing alpha 1-antritrypsin. This method, which uses Pharmalyte pH 4.2-4.9 and a 9.5 cm or 7.0 cm inter-electrode wick distance, clearly resolves the M1, M2, M3, S, Z and a number of rare variant allelic products. In addition, a rapid screening method for the detection of the Z, the most deficient variant, using a gel with an electrode wick distance of 5.0 cm, is also efficaceous in the detection of this and other rare allelic products.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/elps.1150061012
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