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  • 1985-1989  (5)
  • Biochemistry and Biotechnology  (3)
  • Gastroduodenal ulcer  (2)
  • Nuclear Reactions
  • 1
    Electronic Resource
    Electronic Resource
    182. Verfahrenswahl beim perforierten Gastroduodenalulcus: Definitive Operation oder einfache übernähung? (1986)
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 741-741 
    Details
    ISSN: 1435-2451
    Keywords: Gastroduodenal ulcer ; Perforation ; Prognostic criteria ; Indication ; Gastroduodenalulcus ; Perforation ; Prognostische Kriterien ; Verfahrenswahl
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die hohe Morbidität (20–65% Ulcussymptome, 5–20% Ulcuskomplikationen, 20–39% Reoperationen) nach Excision und übernähung bei Patienten mit Ulcusperforation auchohne Ulcusanamnese spricht für die primäre, definitive Operation. Um das erhöhte Operationsrisiko auszuschalten, faßten wir 4 Risikofaktoren (Alter 〉 70, Intervall Perf./Op. 〉 24 h, schwere Begleitkrankheiten, diffuse Peritonitis) und die Ulcusanamnese 〈 3 Monate zu einem 5-Punktesystem zusammen. Patienten mit ≤ 3 Pt. wurden definitiv operiert (Excision/übernähung/PSV oder Resektion), Patienten mit ≥ 4 Pt. nur excidiert und übernäht. Die Gesamtletalität in dieser Serie von 51 Patienten (79–83) war dabei signifikant geringer (2 Patienten verstorben von 51; 4%) als in einer Serie mit grundsätzlicher definitiver Operation (5 verstorben von 64, 8%) (p 〈 0,025).
    Notes: Summary The high morbidity (20%–65% ulcer symptoms, 5%–20% ulcer complications, 20%–39% reoperations) after excision and simple closure of perforated ulcers that also occurs among patientswithout an ulcer history indicates that definitive operation is the treatment of choice. To identify patients with a high risk of mortality, a critical scoring system was devised according to whether the duration of the ulcer history exceeded 3 months and according to four risk factors: (1) age 〉 70 years, (2) time between perforation and operation 〉 24 h, (3) severe concomitant disease, and (4) diffuse peritonitis. Patients who scored ≤ 3 points underwent definitive surgery (excision, closure, proximal gastric vagotomy or partial gastrectomy), and patients who scored ≥ 4 points underwent only excision and simple closure. The overall mortality (2 of 51 patients died) of 4% was significantly lower than that of a previous group (8%) treated with definitive surgery, in which 5 of 64 patients died (p 〈 0.025).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01274500
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    319. Die proximal selektive Vagotomie beim gastroduodenalen Ulcus -10-Jahres-Ergebnisse der europäischen multizentrischen Studie (1987)
    Springer
    Langenbeck's archives of surgery 372 (1987), S. 935-935 
    Details
    ISSN: 1435-2451
    Keywords: Proximal gastric vagotomy ; Gastroduodenal ulcer ; Ten-year results ; Proximal selektive Vagotomie ; Gastroduodenales Ulcus ; 10-Jahres-Ergebnisse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über die 10-Jahres-Ergebnisse einer prospektiven multizentrischen Studie an 8 europäischen Kliniken (Basel, Bern, Düsseldorf, Erlangen, Freiburg, Krefeld, München Klinikum Grosshadern, Strassburg) zur Bewertung der proximal selektiven Vagotomie beim gastroduodenalen Ulcus. Die Nachuntersuchungsrate war 81%. Ergebnis:n symptomatisch total Visick Ulcustyp % Rezidivrate % 1 + II Ulcus duodeni524 13,6 20,4 88% Ulcus ventriculi 71 13,5 19,8 73% Ulcus pyloricum/praepyloricum 94 18,7 31,684% Kombinierte Ulcera 28 27,9 31,7 82%
    Notes: Summary We report the 10-year results of a prospective multicenter trial in eight European centers (Basel, Bern, Düsseldorf, Erlangen, Freiburg, Krefeld, München Klinikum Grosshadern, Strassburg) evaluating proximal gastric vagotomy for gastroduodenal ulcers. The follow-up rate was 81%. Results:n Symptomatic Total Visick Ulcer type recurrencerecurrence I + II (%) (%) Duodenal ulcer 524 13.6 20.488% Gastric ulcer 71 13.5 19.8 73% Pyloric/prepyloric ulcer 94 18.7 31.6 84% Combined ulcer 28 27.9 31.782%
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01298104
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  • 3
    Electronic Resource
    Electronic Resource
    Application of a degenerate consensus sequence to quantify recognition sites by vertebrate DNA topoisomerase II (1989)
    Chicester [u.a.] : Wiley-Blackwell
    Journal of Molecular Recognition 2 (1989), S. 63-74 
    Details
    ISSN: 0952-3499
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A consensus sequence has been derived for vertebrate topoisomerase II cleavage of DNA (Spitzner, J. R. and Muller, M. T. (1988) Nucleic Acid. Res. 16, 5533-5556). An independent sample of 65 topoisomerase II sites (obtained in the absence of topoisomerase II inhibitors) was analyzed and found to match the consensus sequence as well as enzyme sites determined in the presence of the anti-tumor drug 4′-(9-acridinyl-amino)-methanesulfon-manisidide (m-AMSA). As originally described, conventional application of the consensus sequence afforded accuracy in the prediction of the locations but not the frequencies of topoisomerase II cleavages. In the present report, we describe a new method which quantitatively discriminates sites from nonsites, called the ‘matrix mean’ method (the mean match of a site to the matrix of base proportions from the original consensus sequence derivation). Furthermore, we derived a second method, called the ‘unique score’ model, which predicts frequency of topoisomerase II activity at a cleavage site. In the unique score method both DNA strands of a site are examined to determine the total number of the consensus positions that match on at least one strand of a potential site. From the new data base of 65 topoisomerase II sites, cleavages were scored for relative cleavage strength. Linear regression analysis showed a significant (p 〈 0.01) correlation between the unique score and cleavage strength. The study was extended to show that the unique score model accurately and quantitatively predicts topoisomerase II sites either in the absence or presence of m-AMSA using the same consensus sequence.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmr.300020204
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Immobilized pH gradients in capillary tubes and two-dimensional gel electrophoresis (1986)
    Weinheim : Wiley-Blackwell
    Electrophoresis 7 (1986), S. 505-511 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Isoelectric focusing in mixed carrier ampholyte-immobilized pH gradients (CA-IPG) is an effective way to separate proteins by charge. A method to prepare CA-IPG in capillary tubes and the description of the equipment used are outlined. Two-dimensional gel electrophoresis patterns of human serum and liver biopsies, with isoelectric focusing and CA-IPG as the first dimension, are presented. The comparison with two-dimensional gel electrophoresis patterns obtained by conventional carrier ampholyte pH gradient separation shows the excellent resolution and potential of this technique.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150071105
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  • 5
    Electronic Resource
    Electronic Resource
    Automatic classification of two-dimensional gel electrophoresis pictures by heuristic clustering analysis: A step toward machine learning (1988)
    Weinheim : Wiley-Blackwell
    Electrophoresis 9 (1988), S. 136-142 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: The interpretation of two-dimensional gel electrophoresis (2-DGE) profiles can be facilitated by artificial intelligence and machine learning programs. We have incorporated into our 2-DGE computer analysis system (termed MELANIE-Medical Electrophoresis Analysis Interactive Expert system) a program which automatically classifies 2-DGE patterns using heuristic clustering analysis. This program is a step toward machine learning. In this publication, we describe the classification method and the preliminary results obtained with liver biopsy electrophoretograms. Heuristic clustering is also compared to other classification techniques.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150090307
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    Paper (German National Licenses)
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